Ocular Angiogenesis

Diseases, Mechanisms, and Therapeutics

  • Joyce Tombrain-Tink
  • Colin J. Barnstable

Part of the Opthalmology Research book series (OPHRES)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Angiogenic Diseases

    1. Front Matter
      Pages 1-1
    2. Curtis L. Hagedorn, Ron A. Adelman
      Pages 3-22
    3. Jian-Zing Ma, Sarah X. Zhang
      Pages 23-44
    4. Trevor R. Carmichael
      Pages 45-71
    5. Nahoko Ogata, Kanji Takahashi
      Pages 73-84
    6. Kyoko Ohno-Matsui, Takashi Tokoro
      Pages 85-99
    7. Jonathan Stone, Trent Sandercoe, Jan Provis
      Pages 101-126
    8. James C. Tsai, M. Bruce Shields
      Pages 127-147
    9. Jyotirmay Biswas
      Pages 149-159
    10. Nader Sheibani, Daniel M. Albert
      Pages 161-171
    11. Jacquie Greenberg, Ari Ziskind, Stephen P. Daiger
      Pages 173-188
  3. Endogenous Promoters and Inhibitors of Angiogenesis

    1. Front Matter
      Pages 191-191
    2. Sam Dahr, Karl G. Csaky
      Pages 191-204
    3. Andreas Bikfalvi, Sophie Javerzat
      Pages 205-213
    4. Joyce Tombran-Tink, Colin J. Barnstable
      Pages 215-231
    5. Arin Aurora, Olga V. Volpert
      Pages 233-255
    6. Matthew R. Ritter, Martin Friedlander
      Pages 279-289
    7. Chi-Chao Chan, Robert B. Nussenblatt
      Pages 291-305
  4. Therapeutics and Delivery for Angiogenic eye Diseases

    1. Front Matter
      Pages 307-307
    2. Ming Lu, Donald J. D’Amico
      Pages 309-339
    3. Stella M. Robertson, Alberta A. Davis, David C. Dahlin, Abbot F. Clark
      Pages 341-354
    4. Brian J. Raisler, Kenneth I. Berns, William W. Hauswirth
      Pages 355-371
    5. John M. Nickerson, R. Keith Shuler Jr., John B. Davies, Phyllis K. Dioguardi, Steven M. Wolchok, Vincent T. Ciavatta et al.
      Pages 373-391
    6. Heather Sheardown, W. Mark Saltzman
      Pages 393-408
  5. Back Matter
    Pages 409-412

About this book


The recent intense study of pathogenic ocular angiogenesis-an abnormal growth of blood vessels in the eye responsible for the major blinding diseases throughout the world-has yielded an overwhelming flood of scientific findings, novel insights, and possible future therapeutic approaches. In Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics, leading academic and pharmaceutical researchers and clinicians from many disciplines synthesize and summarize these developments to present a comprehensive review of what is known about angiogenesis, its role in blinding diseases, and the mechanisms leading to progressive vessel dysfunction. The authors also identify and assess the most promising approaches with potential for commercial exploitation and discuss the challenges encountered in developing therapeutics for ocular neovascular diseases. Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches.
Comprehensive and multidisciplinary, Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics offers a novel view of the clinical features of pathological angiogenesis in the eye, the molecular and environmental switches that govern vessel growth, and the tremendous opportunities for and progress made in the development of new therapeutics.


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Editors and affiliations

  • Joyce Tombrain-Tink
    • 1
    • 2
  • Colin J. Barnstable
    • 2
  1. 1.Division of Pharmaceutical SciencesUniversity of Missouri-Kansas CityKansas City
  2. 2.Department of Ophthalmology and Visual ScienceYale University School of MedicineNew Haven

Bibliographic information

  • DOI
  • Copyright Information Humana Press Inc. 2006
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-58829-514-9
  • Online ISBN 978-1-59745-047-8
  • Buy this book on publisher's site