From Melanocytes to Melanoma

The Progression to Malignancy

  • Vincent J. Hearing
  • Stanley P. L. Leong

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Melanocyte Development and Function

    1. Front Matter
      Pages 1-1
    2. Debra L. Silver, William J. Pavan
      Pages 3-26
    3. Heinz Arnheiter, Ling Hou, Minh-Thanh T. Nguyen, Keren Bismuth, Tamas Csermely, Hideki Murakami et al.
      Pages 27-49
    4. Erez Feige, Laura L. Poling, David E. Fisher
      Pages 51-69
    5. Zalfa A. Abdel-Malek, Ana Luisa Kadekaro
      Pages 81-100
    6. Yuji Yamaguchi, Vincent J. Hearing
      Pages 101-115
  3. Melanocyte Transformation and Progression to Melanoma

    1. Front Matter
      Pages 117-117
    2. Pablo López Bergam, Anindita Bhoumik, Ze’ev Ronai
      Pages 119-147
    3. Anthony L. Cook, Glen M. Boyle, J. Helen Leonard, Peter G. Parsons, Richard A. Sturm
      Pages 149-167
    4. Dahu Chen, Qiushi Lin, I. Saira Mian, Jon Reed, Estela E. Medrano
      Pages 211-222
    5. Norman E. Sharpless, Lynda Chin
      Pages 265-290
    6. James E. Cleaver
      Pages 291-310
    7. David C. Whiteman, Adèle C. Green
      Pages 311-327
    8. Maria Teresa Landi
      Pages 329-345
    9. Peter A. Kanetsky, Timothy R. Rebbeck
      Pages 347-364
    10. A. Neil Crowson, Cynthia Magro, Martin C. Mihm Jr.
      Pages 365-398
    11. Amanda Pfaff Smith, Dorothea Becker
      Pages 399-408
    12. Katheryn A. Resing, Natalie G. Ahn
      Pages 409-425
  4. Primary Invasive Melanoma to Metastatic Melanoma

    1. Front Matter
      Pages 427-427
    2. Stanley P. L. Leong
      Pages 429-440
    3. Neil A. Accortt, Seng-jaw Soong
      Pages 455-473
    4. Carmen Tellez, Menashe Bar-Eli
      Pages 489-502
    5. Mohammed Kashani-Sabet
      Pages 503-511
    6. David E. Elder
      Pages 513-532
    7. Mary J. C. Hendrix, Elisabeth A. Seftor, Angela R. Hess, Richard E. B. Seftor
      Pages 533-550
    8. Kevin G. Chen, Michael M. Gottesman
      Pages 591-603
    9. Heike Röckmann, Dirk Schadendorf
      Pages 605-617
    10. Rishab K. Gupta, Ana M. McElrath-Garza, Donald L. Morton
      Pages 619-631
    11. Julian A. Kim, Ernest Borden
      Pages 633-649
    12. Vincent J. Hearing, Stanley P. L. Leong
      Pages 651-652
  5. Back Matter
    Pages 653-678

About this book


Melanoma offers an excellent model for cancer biology and an opportunity to understand the progression of a normal skin cell-the melanocyte-to malignancy. In From Melanocytes to Melanoma: The Progression to Malignancy, leading researchers and clinicians join forces to explain how skin cancer develops from its benign precursor cell type. The authors focus on the molecular mechanisms involved in melanogenesis, the malignant transformation of melanocytes, and the further progression of primary melanomas into invasive and metastatic melanomas. They also review recent advances in our understanding of the basic biology of melanocytes and the development, migration, and differentiation of melanoblasts into melanocytes. The text is augmented by four color plates.
Comprehensive and illuminating, From Melanocytes to Melanoma: The Progression to Malignancy, provides pathologists, dermatologists, surgeons, and medical oncologists with an up-to-date understanding of the progressive mechanisms of oncological development in malignant melanoma, a likely model of malignant progress for other types of cancer, and the ongoing development of novel therapeutics.


DNA apoptosis cancer cell genetics imaging immunotherapy melanoma metastasis skin therapy tumor tumor progression

Editors and affiliations

  • Vincent J. Hearing
    • 1
  • Stanley P. L. Leong
    • 2
    • 3
  1. 1.Laboratory of Cell Biology National Cancer InstituteNational Institutes of HealthBethesda
  2. 2.Department of SurgeryUniversity of CaliforniaSan Francisco
  3. 3.School of MedicineSan Francisco

Bibliographic information

  • DOI
  • Copyright Information Humana Press Inc. 2006
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-58829-459-3
  • Online ISBN 978-1-59259-994-3
  • Buy this book on publisher's site