Natural Products

Drug Discovery and Therapeutic Medicine

  • Lixin Zhang
  • Arnold L. Demain

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Fundamental Issues Related to Natural Product-Based Drug Delivery

    1. Front Matter
      Pages 1-1
    2. Arnold L. Demain, Lixin Zhang
      Pages 3-29
  3. Strategies

    1. Front Matter
      Pages 31-31
    2. José R. Tormo, Juan B. García
      Pages 57-75
    3. Chris M. Farnet, Emmanuel Zazopoulos
      Pages 95-106
    4. Stephen B. del Cardayré
      Pages 107-125
  4. Specific Groups of Drugs

    1. Front Matter
      Pages 127-127
    2. David J. Newman, Gordon M. Cragg
      Pages 129-168
    3. Jian Hong, Shu-Hui Chen
      Pages 169-196
    4. Guangyi Wang, Weiping Tang, Robert R. Bidigare
      Pages 197-227
    5. Guo-Qiang Chen, Qiong Wang, Hua Yan, Zhu Chen
      Pages 251-272
  5. Microbial Diversity

    1. Front Matter
      Pages 273-273
    2. Karsten Zengler, Ashish Paradkar, Martin Keller
      Pages 275-293
    3. Asuncion Martinez, Joern Hopke, Ian A. MacNeil, Marcia S. Osburne
      Pages 295-312
  6. Specific Sources

    1. Front Matter
      Pages 313-313
    2. Paul R. Jensen, William Fenical
      Pages 315-328

About this book

Introduction

Although the natural product drug discovery programs of the large drug companies are now equaled by programs for the high throughput screening of synthetic compounds generated through combinatorial chemistry, natural compounds still hold great promise to overcome such problems as antibiotic resistance, the emergence of new diseases, the failure to conquer old diseases, and the toxicity of some contemporary medical products. In Natural Products: Drug Discovery and Therapeutic Medicine, a panel of recognized experts and leaders in the field discuss the past successes of natural products as medicines and review future possibilities arising from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discovery, to accessing microbial diversity, to investigating specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to exploiting specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
State-of-the-art and forward looking, Natural Products: Drug Discovery and Therapeutic Medicine will inspire industrial and academic researchers, practitioners, and developers to once again explore natural products as key sources for the many new drugs needed to solve still unmet medical needs.

Keywords

cancer drug drug delivery drug discovery research

Editors and affiliations

  • Lixin Zhang
    • 1
    • 2
  • Arnold L. Demain
    • 3
  1. 1.Guangzhou Institute of Biomedicine and HealthChinese Academy of SciencesGuangzhouChina
  2. 2.SynerZ Pharmaceuticals Inc.Lexington
  3. 3.Charles A. Dana Research Institute (R.I.S.E.)Drew UniversityMadison

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59259-976-9
  • Copyright Information Humana Press Inc. 2005
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-58829-383-1
  • Online ISBN 978-1-59259-976-9
  • About this book