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Vaccine Adjuvants

Immunological and Clinical Principles

  • Charles J. Hackett
  • Donald A. HarnJr.

Part of the Infectious Disease book series (ID)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Bali Pulendran, Anshu Agrawal, Stephanie Dillon, Sudhanshu Agrawal
    Pages 25-38
  3. Matthew F. Mescher, Julie M. Curtsinger, Marc Jenkins
    Pages 49-67
  4. Kiyoshi Takeda, Hiroaki Hemmi, Shizuo Akira
    Pages 69-86
  5. Ed C. Lavelle, Olive Leavy, Kingston H. G. Mills
    Pages 111-153
  6. Ricardo T. Gazzinelli, Catherine Ropert, Igor C. Almeida, João S. Silva, Marco A. Campos
    Pages 155-175
  7. Mitsuhiro Okano, Kazunori Nishizaki, Akram Da’dara, Paul Thomas, Michele Carter, Donald A. Harn Jr.
    Pages 177-191
  8. Charlotte Read Kensil, Gui Liu, Christine Anderson, James Storey
    Pages 221-234
  9. Jory Baldridge, Kent Myers, David Johnson, David Persing, Christopher Cluff, Robert Hershberg
    Pages 235-255
  10. Kimberly Denis-Mize, Manmohan Singh, Derek T. O’Hagan, Jeffrey B. Ulmer, John J. Donnelly
    Pages 257-270
  11. Back Matter
    Pages 271-284

About this book

Introduction

Recent major advances in our understanding of basic immunology have led to the development of powerful new adjuvants-substances that can stimulate the innate immune system and significantly improve the effectiveness of antigen-based vaccines. In Vaccine Adjuvants: Immunological and Clinical Principles, highly respected clinical immunologists and vaccine researchers detail the major research areas in this new era of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use. The focus is on specific receptor-ligand interactions, including the molecular features needed for a compound to possess adjuvant activity. The critical interface zone between the innate and adaptive immune systems is also analyzed to show how adjuvants exert their effects on T- and B-cell activation. Additional chapters address the possibility of tailoring adjuvants to yield optimally safe and effective responses. Among the highlights are an explanation of innate immune signaling-including Toll-like receptors-in vaccination, and a preview of emerging technologies in adjuvant research, such as microparticles and novel lipid and carbohydrate adjuvants.
Authoritative and eminently practical, Vaccine Adjuvants: Immunological and Clinical Principles moves from the basic principles of the innate immune system, through the characteristics of specific adjuvants, to detailed methods for developing the safer and more effective adjuvants that will trigger these powerful immune responses, and finally to the combinations of immune responses needed for successful vaccination.

Keywords

Antigen bacteria genes lipide parasite parasites pathogenesis protein research vaccine

Editors and affiliations

  • Charles J. Hackett
    • 1
  • Donald A. HarnJr.
    • 2
  1. 1.Division of Allergy, Immunology, and Transplantation National Institute of Allergy and Infectious DiseasesNIHBethesda
  2. 2.Department of Immunology and Infectious DiseaseHarvard School of Public HealthBoston

Bibliographic information