Dopamine and Glutamate in Psychiatric Disorders

1. Front Matter

   Pages i-xiv

   PDF

2. Dopamine

   1. Front Matter

      Pages 1-1

      PDF

   2. Dopamine Receptors

      • Kim A. Neve

      Pages 3-43

   3. Dopamine Receptor Alternative Splicing

      • Neil M. Richtand, Laurel M. Pritchard, Lique M. Coolen

      Pages 45-61

3. Glutamate

   1. Front Matter

      Pages 63-63

      PDF

   2. Glutamatergic Pathways

      • Yoland Smith

      Pages 65-77

   3. Glutamate Receptors

      • Daniel T. Monaghan, Julia C. A. More, Bihua Feng, David E. Jane

      Pages 79-116

   4. Metabotropic Glutamate Receptors

      • Krystyna Ossowska

      Pages 117-149

4. Schizophrenia

   1. Front Matter

      Pages 151-151

      PDF

   2. Dopamine and Schizophrenia

      • Bart A. Ellenbroek

      Pages 153-168

   3. Glutamate and Schizophrenia and the N-Methyl-d-Aspartate Receptor Hypofunction Hypothesis

      • Stefan Bleich, Johannes Kornhuber

      Pages 169-179

   4. Role of Glycine in Schizophrenia

      • Beate D. Kretschmer

      Pages 181-195

5. Depression

   1. Front Matter

      Pages 197-197

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   2. Dopamine and Depression

      • Phil Skolnick

      Pages 199-214

   3. Glutamate and Depression

      • Joaquín Del Río, Diana Frechilla

      Pages 215-234

6. Stress and Aggression

   1. Front Matter

      Pages 235-235

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   2. Dopamine, Glutamate, and Aggression

      • Klaus A. Miczek, Eric W. Fish

      Pages 237-263

7. Anxiety

   1. Front Matter

      Pages 265-265

      PDF

   2. Glutamatergic Systems and Anxiety

      • David N. Stephens

      Pages 267-289

8. Attention Deficit Hyperactivity Disorder

   1. Front Matter

      Pages 291-291

      PDF

An illuminating summary of our current understanding of the interactive role of dopamine and glutamate in psychiatric diseases and the therapeutic strategies and possibilities for future treatment. Among the new ideas presented are hypotheses on the role of dopamine and glutamate in aggression, the glutamate system in anxiety disorders, glutamate and neurodegeneration, and on the origin and progression of Parkinson's disease. Additional chapters offer novel insights into a variety of psychiatric diseases, including ADHD, stress, aggression, addiction, schizophrenia, depression, social phobias, dementias, bulimia, and neurodegenerative diseases like Parkinson's and Alzheimer's diseases. Each chapter summarizes the prevalence and symptoms of the disease and explains the involvement of dopamine and/or glutamate systems using the newer molecular approaches such as transgenic knockout or knockin mice and recent brain imaging techniques.

• Alzheimer
• Parkinson
• attention
• attention deficit hyperactivity disorder (ADHD)
• biochemistry
• dementia
• depression
• dopamine
• hyperactivity
• psychiatric disorder

"...offers an excellent review of our understanding of how dopamine and glutamate influence the pathophysiology of psychiatric disease...an impressive effort, and every psychiatrist (and neurologist) should have this book in their reference library." - 4 Stars, Doody's Health Sciences and Book Review Journal

• Department of Neuropharmacology Zoological Institute, University of Tübingen, Tübingen, Germany

  Werner J. Schmidt

• Department of Psychiatry, New York University School of Medicine, New York

  Maarten E. A. Reith

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