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DNA Repair in Cancer Therapy

  • Lawrence C. Panasci
  • Moulay A. Alaoui-Jamali

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Brian Leyland-Jones
    Pages 1-7
  3. Bertrand J. Jean-Claude
    Pages 51-71
  4. Istvan Boldogh, Kishor K. Bhakat, Dora Bocangel, Gokul C. Das, Sankar Mitra
    Pages 73-108
  5. Moulay A. Alaoui-Jamali, P. James Scrivens, Martin Loignon
    Pages 109-141
  6. Dindial Ramotar, Huijie Wang, Chaunhua He
    Pages 171-196
  7. Michèle Rouleau, Guy G. Poirier
    Pages 197-210
  8. George Shenouda
    Pages 257-272
  9. Despina Moshous, Jean-Pierre de Villartay
    Pages 273-293
  10. Jennifer J. Hu
    Pages 339-351
  11. Back Matter
    Pages 353-363

About this book

Introduction

Because of drug resistance, currently available anticancer therapies-drugs, radiotherapy, and other biological agents-have limited efficacy in treating cancer. In DNA Repair in Cancer Therapy, leading cancer researchers and oncologists comprehensively review the many recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limit its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Inhibitors of such other DNA repair enzymes as PARP and DNA-PK, now under development and close to clinical trials, are also examined.
Comprehensive and cutting-edge, DNA Repair in Cancer Therapy surveys-for both cancer researchers and practicing oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.

Keywords

BRCA DNA apoptosis cancer treatment cell cell death clinical trial prevention radiotherapy tumor tumorigenesis

Editors and affiliations

  • Lawrence C. Panasci
    • 1
  • Moulay A. Alaoui-Jamali
    • 1
  1. 1.Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General HospitalMcGill UniversityMontrealCanada

Bibliographic information