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Voltammetry in the Neurosciences

Principles, Methods, and Applications

  • Joseph B. JusticeJr.

Part of the Contemporary Neurosciences book series (CNEURO)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Fundamentals of in Vivo Voltammetry

    1. Front Matter
      Pages 1-1
    2. Joseph B. Justice Jr.
      Pages 3-101
    3. R. Mark Wightman, David S. Brown, Werner G. Kuhr, Robert L. Wilson
      Pages 103-138
    4. James O. Schenk, B. S. Bunney
      Pages 139-160
  3. Application to the Neurochemistry of Catecholamines

    1. Front Matter
      Pages 161-161
    2. Joseph B. Justice Jr., Adrian C. Michael
      Pages 185-208
    3. C. A. Marsden, K. F. Martin, M. P. Brazell, N. T. Maidment
      Pages 209-237
    4. Michel Buda, François G. Gonon
      Pages 239-272
  4. Voltammetry and Behavior

    1. Front Matter
      Pages 311-311
    2. Toshiharu Nagatsu, Masato Ikeda, Keisuke Fujita, Masanori Shinzato, Hisahide Takahashi, Toshio Adachi
      Pages 313-324
  5. Back Matter
    Pages 375-383

About this book

Introduction

Even before the time of organized scientific investigation, hu­ mans had begun pondering and attempting to explain the work­ ing of the brain and the mental and behavioral states it produces. In the last twenty years there has been an almost explosive in­ crease in brain research. Beginning perhaps with the pioneering efforts of Francis O. Schmitt to establish the Neuroscience Re­ search Program and the later development of the Society for Neuroscience, there has emerged a large and powerful multi­ disciplinary research force devoted to understanding even the ru­ dimentary aspects of brain functioning. Chemists, physicists, and engineers with their special expert­ ise in quantitative physical measurements have teamed up with the neurobiologists, who best know the texture and design of brains, to produce particularly effective new approaches. No­ where is this more evident than in the recently developed meth­ ods like positron emission tomography and magnetic resonance imaging-techniques that allow one to observe on-going brain ac­ tivity in humans. This volume concerns a considerably more modest approach: the use of microelectrodes to electrochemically monitor certain aspects of chemical dynamics in functioning ani­ mal brain systems. The method provides signals that can be di­ rectly related to chemical neurotransmission. It is a relatively new technique, the first practical measurements having been made in the 1970s, and it is continuously undergoing refinement. The organizer of this book, Jay Justice, is eminently qualified for the task.

Keywords

brain catecholamines dopamine magnetic resonance imaging (MRI) neurochemistry neurons neuroscience positron emission tomography (PET) receptor regulation

Editors and affiliations

  • Joseph B. JusticeJr.
    • 1
  1. 1.Department of ChemistryEmory UniversityAtlantaUSA

Bibliographic information