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Drug Delivery Systems in Cancer Therapy

  • Dennis M. Brown

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-x
  2. Pharmacological Considerations for Drug Delivery Systems in Cancer Medicine

    1. Front Matter
      Pages 1-1
    2. Reginald B. Ewesuedo, Mark J. Ratain
      Pages 3-14
    3. Ardith W. El-Kareh, Timothy W. Secomb
      Pages 25-43
  3. Technologies Available for Use in Cancer Drug Delivery Systems

    1. Front Matter
      Pages 45-45
    2. Sung-Joo Hwang, Namjin Baek, Haesun Park, Kinam Park
      Pages 97-115
    3. Duane T. Birnbaum, Lisa Brannon-Peppas
      Pages 117-135
    4. Robert G. L. Shorr, Michael Bentley, Simon Zhsao, Richard Parker, Brendan Whittle
      Pages 137-174
    5. S. Esmail Tabibi
      Pages 175-187
  4. Current Applications

    1. Front Matter
      Pages 189-189
    2. Daryl C. Drummond, Dmitri Kirpotin, Christopher C. Benz, John W. Park, Keelung Hong
      Pages 191-213
    3. Francesco DiMeco, Henry Brem, Jon D. Weingart, Alessandro Olivi
      Pages 215-228
    4. Sankaram B. Mantripragada, Stephen B. Howell
      Pages 247-262
    5. Susanne Osanto
      Pages 263-284
  5. Future Directions

    1. Front Matter
      Pages 285-285
    2. Susanne Osanto
      Pages 287-310
    3. Stanley T. Crooke
      Pages 311-345
    4. Francesco M. Marincola
      Pages 347-360
  6. Back Matter
    Pages 377-390

About this book

Introduction

A major difficulty in successfully treating cancer with drugs is achieving adequate drug concentrations in the diseased areas without overexposing drug-sensitive normal tissues. In a number of cases, specialized drug delivery systems are required to realize a therapeutic gain. In Drug Delivery Systems in Cancer Therapy, Dennis M. Brown has assembled a panel of leading experts to survey all the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. They also profile the use of novel formulation technologies-including synthetic polymers and biomaterials for sustained drug release to achieve greater therapeutic effect-that have demonstrated efficacy in a number of approved and late-stage clinical products. They also consider the benefits of, and future opportunities for, various drug delivery systems, as well as the experimental techniques used in their evaluation. Although the focus is primarily on small molecule delivery, many of the technologies described can also be effective in delivering larger biomolecules.
Comprehensive, cutting-edge, and highly practical, Drug Delivery Systems in Cancer Therapy captures for experimental oncologists, medicinal chemists, and pharmacologists the universe of approaches, technologies, and systems available for substantially enhancing the therapeutic outcome of anticancer drug delivery today.

Keywords

brain tumors cancer cancer therapy cancer treatment chemotherapy drug drug delivery gene therapy tumor vaccine

Editors and affiliations

  • Dennis M. Brown
    • 1
  1. 1.ChemGenex Therapeutics, Inc.Menlo ParkUSA

Bibliographic information