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Cell Cycle Inhibitors in Cancer Therapy

Current Strategies

  • Antonio Giordano
  • Kenneth J. Soprano

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-x
  2. Giulia De Falco, Catherine Soprano, Antonio Giordano
    Pages 1-10
  3. André J. van Wijnen, Gary S. Stein, Janet L. Stein, Jane B. Lian
    Pages 31-48
  4. Lorenzo Leoncini, Cristiana Bellan, Caterina Cinti, Antonio Giordano
    Pages 49-82
  5. Lucio Miele
    Pages 83-118
  6. Joanna K. Sax, Wafik S. El-Deiry
    Pages 119-143
  7. Kenneth J. Soprano, Sijie Zhang, Dongmei Zhang, William F. Holmes, Valeria Masciullo, Antonio Giordano et al.
    Pages 145-177
  8. Adrian M. Senderowicz
    Pages 179-205
  9. Paul J. van Diest, Rob J. A. M. Michalides
    Pages 207-252
  10. Mikhail V. Blagosklonny
    Pages 253-275
  11. Valeria Masciullo, Kenneth J. Soprano, Antonio Giordano
    Pages 277-296
  12. Anna Severino, Armando Felsani, Antonio Giordano, Marco G. Paggi
    Pages 297-310
  13. Back Matter
    Pages 311-326

About this book

Introduction


The molecular approach to disease continues to yield a tremendous amount of new information about those aspects of cellular replication that we use to understand, prevent, diagnose, and cure cancer. In Cell Cycle Inhibitors in Cancer Therapy: Current Strategies, recognized clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell-cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor-suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac.
Up-to-date and richly instructive, Cell Cycle Inhibitors in Cancer Therapy: Current Strategies brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.

Keywords

AIDS apoptosis cancer cancer therapy cardiovascular disease cell diagnostics molecular biology prevention research tumor

Editors and affiliations

  • Antonio Giordano
    • 1
  • Kenneth J. Soprano
    • 2
  1. 1.Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and TechnologyTemple UniversityPhiladelphiaUSA
  2. 2.Department of Microbiology and ImmunologyTemple University School of MedicinePhiladelphiaUSA

Bibliographic information