Natural Products Isolation

  • Richard J. P. Cannell

Part of the Methods in Biotechnology book series (MIBT, volume 4)

Table of contents

  1. Front Matter
    Pages i-x
  2. Richard J. P. Cannell
    Pages 1-51
  3. F. Patrick Gailliot
    Pages 53-89
  4. Ed Venkat, Srinivas Kothandaraman
    Pages 91-109
  5. Gino M. Salituro, Claude Dufresne
    Pages 111-140
  6. Claude Dufresne
    Pages 141-164
  7. Paul Stead
    Pages 165-208
  8. Simon Gibbons, Alexander I. Gray
    Pages 209-245
  9. Norman Shankland, Alastair J. Florence, Richard J. P. Cannell
    Pages 261-278
  10. Frank Van Middlesworth, Richard J. P. Cannell
    Pages 279-327
  11. Yuzuru Shimizu
    Pages 329-341
  12. Gloria L. Silva, Ik-Soo Lee, A. Douglas Kinghorn
    Pages 343-363
  13. Amy E. Wright
    Pages 365-408
  14. Michael S. Verrall, Stephen R. C. Warr
    Pages 409-424
  15. Richard J. P. Cannell
    Pages 425-463
  16. Back Matter
    Pages 465-473

About this book

Introduction

Natural Products Isolation provides a comprehensive introduction to techniques for the extraction and purification of natural products from all biological sources. The book opens with an introduction to separations and chromatography and discusses the approach to an isolation. Experienced experimentalists describe a wide array of methods for isolation of both known and unknown natural products, including initial extraction, open column chromatography, HPLC, countercurrent and planar chromatography, SFE, and crystallisation. Later chapters address specific issues in working with plants, marine organisms, water-soluble compounds, as well as scale-up, dereplication and follow-up of a natural product lead. For the less experienced, these chapters provide background information and hands-on advice - using real examples - about how to approach an extraction in general, when and how to apply a particular technique and how to modify conditions according to the nature of the compound being isolated.

Geared to scientists with little experience of natural products extraction, but offering even skilled researchers valuable advice and insight, Natural Products Isolation lays the foundation for the potential extractor to isolate natural substances efficiently. Its methods and guidance will almost certainly play a major role in today's natural product discovery and development.










Editors and affiliations

  • Richard J. P. Cannell
    • 1
  1. 1.Glaxo Wellcome Research & DevelopmentStevenageUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59259-256-2
  • Copyright Information Humana Press 1998
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-362-7
  • Online ISBN 978-1-59259-256-2
  • Series Print ISSN 1940-6061
  • Series Online ISSN 1940-607X
  • About this book