Drug Development

Molecular Targets for GI Diseases

  • Timothy S. Gaginella
  • Antonio Guglietta

Table of contents

  1. Front Matter
    Pages i-ix
  2. John L. Wallace
    Pages 1-20
  3. Alan D. Levine, Claudio Fiocchi
    Pages 61-87
  4. Antonio Guglietta, Marija Veljača
    Pages 89-112
  5. Peter Holzer
    Pages 113-146
  6. Massimo D’Amato, Francesco Makovec, Lucio C. Rovati
    Pages 147-176
  7. Sushil K. Sarna, Michel R. Briefer, Jan A. J. Schuurkes
    Pages 177-202
  8. Pierre J. M. Rivière, Jean-Louis Junien
    Pages 203-238
  9. Gabriella Coruzzi, Enzo Poli, Giuseppina Morini, Giulio Bertaccini
    Pages 239-267
  10. Back Matter
    Pages 269-278

About this book

Introduction

Drug Development: Molecular Targets for Gastrointestinal Disease brings together a panel of distinguished experts to critically review the many promising new areas of gastrointestinal pharmacology at the molecular level. Key chapters discuss such major themes as the cyclooxygenase-2 inhibitors, the complexities of nitric oxide pathways in the gut, and the influence of cytokines on inflammatory bowel disease, as well as new opportunities for pharmacotherapy, including peptide growth factors, tachykinins-particularly substance P and neurokinins-cholecystokinin receptors, and serotonin. Also examined as possible sites for treating motility disorders and visceral pain are the opioid receptors residing in the gut, and the H3-receptor agonists for treating gut inflammation and pain. Drug Development: Molecular Targets for Gastrointestinal Disease provides a comprehensive review of today's molecular pharmacological approaches to the discovery and development of novel drugs for gastrointestinal and liver diseases. Its extensive references, richly experienced contributors, and cutting-edge syntheses of past, present, and emergent research establish the book as an essential resource for all pharmacologists, medicinal chemists, and clinicians seeking more powerful drugs for the prevention and treatment of gastrointestinal disorders.

Keywords

cytokine development drug drug development drugs inflammation liver liver disease opioid peptides pharmacology pharmacotherapy serotonin

Editors and affiliations

  • Timothy S. Gaginella
    • 1
  • Antonio Guglietta
    • 2
  1. 1.School of PharmacyUniversity of WisconsinMadisonUSA
  2. 2.Parke-Davis Pharmaceutical Research DivisionAnn ArborUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59259-202-9
  • Copyright Information Humana Press 2000
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-61737-087-8
  • Online ISBN 978-1-59259-202-9
  • About this book