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Tumor Targeting in Cancer Therapy

  • Michel Pagé

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-x
  2. A Review

    1. Front Matter
      Pages 1-1
    2. Tarunendu Ghose
      Pages 3-78
    3. Tarunendu Ghose
      Pages 79-105
  3. Targeting Tumors with Drug Antibody Conjugates

    1. Front Matter
      Pages 107-107
    2. Huaitian Liu, Dianne L. Newton, Hans J. Hansen, Stanislaw M. Mikulski, David M. Goldenberg, Edward A. Sausville et al.
      Pages 109-118
    3. Paul Tardi, Ludger Ickenstein, Marcel Bally, Lawrence Mayer
      Pages 119-135
    4. Brigitte Pagé, Michel Pagé
      Pages 137-149
    5. Mandip Singh
      Pages 151-164
    6. Geoffrey A. Pietersz, Ian F. C. McKenzie
      Pages 179-196
  4. Targeting Tumors with Antibodies

    1. Front Matter
      Pages 197-197
    2. Przemek Twardowski, Kim Margolin
      Pages 199-210
    3. Christian Buske, W. Hiddemann
      Pages 211-223
    4. Roland Newman
      Pages 225-237
    5. Philip R. Hamann, Mark S. Berger
      Pages 239-254
  5. Targeting Tumors with Radioimmunoconjugates

    1. Front Matter
      Pages 255-255
  6. Targeting Tumors with Immunotoxins

    1. Front Matter
      Pages 277-277
    2. Manish Monga, Richard A. Messmann, Edward A. Sausville
      Pages 279-288
    3. Silvana Canevari, Maria Ines Colnaghi, Luigi Cattel, Franco Dosio
      Pages 289-305
    4. Paul LaPointe, Jean Gariépy
      Pages 307-318
  7. Targeting Tumors with Antibody-Enzyme Conjugates (ADEPT)

    1. Front Matter
      Pages 319-319
  8. Photodynamic Therapy

    1. Front Matter
      Pages 327-327
    2. Cynthia M. Allen, Wesley M. Sharman, Johan E. van Lier
      Pages 329-361
  9. Targeting Tumors with Magnetic Drugs

    1. Front Matter
      Pages 377-377
    2. Andreas S. Lübbe, Christian Bergemann, Christoph Alexiou
      Pages 379-388
  10. Principles and Techniques in Targeting

    1. Front Matter
      Pages 389-389
    2. Jairo Jaime Correa
      Pages 391-409
    3. Francesco M. Veronese, Paulo Caliceti
      Pages 411-429
    4. Douglas A. Lappi
      Pages 449-457
  11. Back Matter
    Pages 459-463

About this book

Introduction

After many years of vigorous effort, the use of antibodies to target tumors has become highly successful both clinically and commercially. In Tumor Targeting in Cancer Therapy, Dr. Michel Pagé and a panel of authoritative experts from the drug industry, clinics, and academia introduce the principles and techniques of tumor targeting and critically survey their applications from laboratory to bedside. By concisely synthesizing the many technical details, the authors illuminate this innovative technique, ranging from the fundamentals of drug targeting and in vivo and in vitro experimentation, to such emerging therapeutic uses as radioimmunotherapy, radioimmunodetection, therapy with cytotoxic antibodies, immunotoxins, enzyme prodrug immunotherapy, and immunotherapeutics with fusion proteins. There are also reviews of targeting tumors with radioimmunoconjugates, photodynamic therapy, and magnetic drugs, as well as discussions of the internalization of antibodies, bioconjugation and biodistribution, the use of cytotoxic drugs, and the pros and cons of targeting by antibody or ligand.
Comprehensive and practical, Tumor Targeting in Cancer Therapy summarizes the essentials of tumor targeting as it is practiced today and provides all those engaged in experimental and clinical cancer research the critically established information needed to evaluate new technologies, investigate novel therapeutic agents, and apply them in relevant clinical practice.

Keywords

antibody-targeted chemotherapy cancer cancer therapy chemistry chemotherapy drug drug resistance immunotherapy lymphoma resistance tumor

Editors and affiliations

  • Michel Pagé
    • 1
  1. 1.Department of Medical Biology, Faculty of MedicineUniversité LavalSainte-FoyCanada

Bibliographic information