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Selective Estrogen Receptor Modulators

Research and Clinical Applications

  • Andrea Manni
  • Michael F. Verderame

Part of the Contemporary Endocrinology book series (COE)

Table of contents

  1. Front Matter
    Pages i-x
  2. Molecular Mechanisms of Estrogen Receptor Function

    1. Front Matter
      Pages 1-1
    2. Stefan Nilsson, Jan-Åke Gustafsson
      Pages 3-18
    3. Paul Webb
      Pages 57-76
  3. Tissue-Specific Effects of Estrogens and SERMs

    1. Front Matter
      Pages 97-97
    2. Munish K. Goyal, Suzanne Oparil
      Pages 99-119
    3. Bruce S. McEwen, Phyllis M. Wise, Stanley Birge
      Pages 121-144
  4. Preclinical Studies

    1. Front Matter
      Pages 145-145
    2. Csaba Gajdos, James Zapf, V. Craig Jordan
      Pages 147-165
    3. Fernand Labrie, Claude Labrie, Alain Bélanger, Jacques Simard
      Pages 167-187
  5. Organ Specific Effects of Estrogens and SERMs

    1. Front Matter
      Pages 189-189
    2. Nanette F. Santoro, Peter Kovacs
      Pages 191-206
    3. Jacques E. Rossouw
      Pages 207-222
    4. Michael Kleerekoper, Ashish Verma
      Pages 237-243
    5. Aurelie Fontana, Pierre D. Delmas
      Pages 245-254
    6. Alan J. Lerner
      Pages 255-264
  6. SERMs and Endocrine Dependent Tumors

    1. Front Matter
      Pages 265-265
    2. Jenny Chang, C. Kent Osborne
      Pages 267-278
    3. Jan L. Shifren, Leo Plouffe Jr.
      Pages 279-295
  7. Roles of Estrogens and SERMs in Postmenopausal Hormone Replacement Therapy

    1. Front Matter
      Pages 297-297
    2. Nananda F. Col, Michele G. Cyr, Anne W. Moulton
      Pages 299-312
    3. Richard J. Santen, JoAnn V. Pinkerton
      Pages 313-343
    4. Susan R. Davis
      Pages 345-363
  8. Back Matter
    Pages 365-373

About this book

Introduction

Hormone replacement therapy with selective estrogen receptor modulators (SERMs) promises the highly desirable benefits of estrogen and progesterone replacement therapy, while avoiding their associated risks of breast and uterine cancer, gallbladder disease, and weight gain. In Selective Estrogen Receptor Modulators: Research and Clinical Applications, leading experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of coactivators and corepressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentations review the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A novel approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer.
Multidisciplinary and state-of-the-art, Selective Estrogen Receptor Modulators: Research and Clinical Applications provides experimentalists and clinicians alike a comprehensive overview of the basic mechanisms of estrogen and SERMs action, as well as evidence-based guidelines for their clinical use in postmenopausal women.

Keywords

estrogen action estrogen receptor growth growth factor hormone

Editors and affiliations

  • Andrea Manni
    • 1
  • Michael F. Verderame
    • 1
  1. 1.Division of Endocrinology, Diabetes, and Metabolism, Milton S. Hershey Medical CenterPennsylvania State University College of MedicineHersheyUSA

Bibliographic information