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Clinical and Forensic Applications of Capillary Electrophoresis

  • John R. Petersen
  • Amin A. Mohammad

Part of the Pathology and Laboratory Medicine book series (PLM)

Table of contents

  1. Front Matter
    Pages i-x
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Manjiri Lele, Subodh M. Lele, John R. Petersen, Amin Mohammad
      Pages 3-19
  3. Protein Electrophoresis

    1. Front Matter
      Pages 59-59
    2. Kannan Srinivasan, Chris Pohl, Nebojsa Avdalovic
      Pages 61-78
    3. John R. Petersen, Amin A. Mohammad
      Pages 105-112
    4. Rainer Lehmann
      Pages 113-144
    5. James M. Hempe, Alfonso Vargas, Randall D. Craver
      Pages 145-163
  4. Metabolic Diseases

    1. Front Matter
      Pages 165-165
    2. Mary Kathryn Linde
      Pages 167-192
    3. Kern L. Nuttall, Norberto A. Guzman
      Pages 193-208
    4. Cecilia Youh, Amin A. Mohammad, John R. Petersen
      Pages 209-219
  5. Immunoassay

    1. Front Matter
      Pages 221-221
    2. Bode Adesoji, Amin A. Mohammad, John R. Petersen
      Pages 223-233
  6. Molecular Diagnostics

  7. Mass Spectrometry, Therapeutic Drug Monitoring, and Toxicology

    1. Front Matter
      Pages 315-315
    2. Lokinendi V. Rao, John R. Petersen, Amin A. Mohammad, Anthony O. Okorodudu
      Pages 385-395
    3. Wolfgang Thormann, Jitka Caslavska
      Pages 397-422
    4. John C. Hudson, Murray J. Malcolm, Mauro Golin
      Pages 423-436
  8. Back Matter
    Pages 437-453

About this book

Introduction

Because capillary electrophoresis (CE) is driving the automation of manual and semi-manual techniques, conserves precious samples, and minimizes the use of hazardous organic chemicals, it constitutes a powerful new methodology for the clinical laboratory. In Clinical and Forensic Applications of Capillary Electrophoresis, John R. Petersen and Amin A. Mohammad, along with a panel of leading basic and clinical investigators, review those CE methods that are now replacing many routine serum and blood tests in clinical and forensic laboratories. Major areas reviewed include the coating of columns; the analysis of serum, urine, and CSF proteins and paraproteins; abnormal hemoglobins and hemoglobin Alc; peptides, amino and organic acids; therapeutic drugs; drugs of abuse; viral load; and short tandem repeats (STR). The methods discussed include capillary zone, micellar, electrokinetic, capillary gel, and nonaqueous electrophoresis. The authors show how a variety of detection methods (UV-visible, fluorescence, and MS) can be used in conjunction with CE to detect a broad array of analytes, ranging from serum proteins to PCR products to drugs of forensic importance.
Innovative and highly practical, Clinical and Forensic Applications of Capillary Electrophoresis demonstrates the power and versatility of CE-not only to develop new assays, but also to markedly simplify today's clinical and forensic laboratory methodology.

Keywords

Laboratory diagnostics screening steroids toxicology

Editors and affiliations

  • John R. Petersen
    • 1
  • Amin A. Mohammad
    • 1
  1. 1.University of Texas Medical BranchGalvestonUSA

Bibliographic information