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Antimalarial Chemotherapy

Mechanisms of Action, Resistance, and New Directions in Drug Discovery

  • Philip J. Rosenthal

Part of the Infectious Disease book series (ID)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Philip J. Rosenthal, Louis H. Miller
      Pages 3-13
    3. Steven R. Meshnick, Mary J. Dobson
      Pages 15-25
    4. Kasturi Haldar, Thomas Akompong
      Pages 27-41
    5. Ritu Banerjee, Daniel E. Goldberg
      Pages 43-63
    6. Piero L. Olliaro, Peter B. Bloland
      Pages 65-83
  3. Established Antimalarial Drugs and Compounds Under Clinical Development

    1. Front Matter
      Pages 85-85
    2. Leann Tilley, Paul Loria, Mick Foley
      Pages 87-121
    3. Ralf P. Brueckner, Colin Ohrt, J. Kevin Baird, Wilbur K. Milhous
      Pages 123-151
    4. Grant Dorsey, David A. Fidock, Thomas E. Wellems, Philip J. Rosenthal
      Pages 153-172
    5. Christopher V. Plowe
      Pages 173-190
    6. Steven R. Meshnick
      Pages 191-201
    7. Akhil B. Vaidya
      Pages 203-218
    8. Piero L. Olliaro, Wilbur K. Milhous
      Pages 219-232
  4. New Compounds, New Approaches, and New Targets

    1. Front Matter
      Pages 233-233
    2. Paul A. Stocks, Kaylene J. Raynes, Stephen A. Ward
      Pages 235-253
    3. Gary H. Posner, Mikhail Krasavin, Michael McCutchen, Poonsakdi Ploypradith, John P. Maxwell, Jeffrey S. Elias et al.
      Pages 255-263
    4. Barbara Clough, R. J. M. Wilson
      Pages 265-286
    5. Pradipsinh K. Rathod
      Pages 287-306
    6. Mark Loyevsky, Victor R. Gordeuk
      Pages 307-324
    7. Philip J. Rosenthal
      Pages 325-345
    8. Henri Joseph Vial, Michèle Calas
      Pages 347-365
  5. Back Matter
    Pages 385-396

About this book

Introduction

At a time when the control of malaria is increasingly limited by the growing resistance of malaria parasites to available drugs, the need for a much better use of the existing drugs, as well as for the development of new antimalarials, has become urgent. In Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery, a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. The survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, and new chemical approaches to and possible new targets for chemotherapy. It also discusses, as essential background, the history of chemotherapy, the practical aspects of therapy, and the public health consequences of current problems in antimalarial chemotherapy.
Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

Keywords

Malaria antibiotics biochemistry chemotherapy clinical research drug drug discovery drug resistance lipide metabolism research resistance

Editors and affiliations

  • Philip J. Rosenthal
    • 1
  1. 1.School of MedicineUniversity of CaliforniaSan FranciscoUSA

Bibliographic information