The Neuronal Environment

Brain Homeostasis in Health and Disease

  • Wolfgang Walz

Part of the Contemporary Neuroscience book series (CNEURO)

Table of contents

  1. Front Matter
    Pages i-x
  2. Neuronal Activity and Its Dependence on the Microenvironment

    1. Front Matter
      Pages 1-1
    2. Stephen Dombrowski, Imad Najm, Damir Janigro
      Pages 3-24
    3. Avital Schurr
      Pages 25-54
  3. Brain Microenvironment

    1. Front Matter
      Pages 55-55
    2. Eva Syková
      Pages 57-81
    3. Anders Jansson, Laurent Descarries, Virginia Cornea-Hébert, Mustapha Riad, Daniel Vergé, Mircea Bancila et al.
      Pages 83-108
    4. Jeremy Garwood, Nicolas Heck, Franck Rigato, Andreas Faissner
      Pages 109-158
    5. Wolfgang Walz, Bernhard H. J. Juurlink
      Pages 159-185
    6. Jeffery D. Kocsis
      Pages 211-231
  4. Brain Macroenvironment

    1. Front Matter
      Pages 259-259
    2. Richard F. Keep
      Pages 277-307
    3. James W. Anderson, Alastair V. Ferguson
      Pages 309-339
    4. Marc R. Del Bigio
      Pages 341-375
  5. Immune System-Neuron Interactions

    1. Front Matter
      Pages 377-377
    2. Sophie Chabot, V. Wee Yong
      Pages 379-400
    3. Hiroyuki Kato, Takanori Oikawa
      Pages 401-417
  6. Back Matter
    Pages 419-432

About this book


To function properly, neurons must interact with other constituent elements of the brain (e.g., blood supply and myelin), and in fact most diseases of the nervous system involve these nonneuronal components. In The Neuronal Environment: Brain Homeostasis in Health and Disease, leading neuroscience researchers offer a fresh perspective on neuronal function by examining all its many components-including their pertubation during major disease states-and relate each element to neuronal demands. Topics range from the dependency of neurons on metabolic supply, ion homeostasis, and transmitter homeostasis, to their close interaction with the myelin sheath. Also addressed are the astrocytic signaling system, which controls synaptic transmission, the extracellular matrix and space as communication systems, the role of blood flow regulation in blood-brain barrier function, and inflammation and the neuroimmune system. All these elements are treated in the context of their importance for neurons and the major diseases affecting them.
Insightful and integrative, The Neuronal Environment: Brain Homeostasis in Health and Disease demonstrates for today's neuroscientists, cell biologists, and pharmacologists a clear new understanding that neurons do not work in isolation, that they need constant interactions with other brain components to process information, and that they are not the brain's sole information processing system.


Flow Nervous System dopamine information processing neurons neuroscience physiology regulation

Editors and affiliations

  • Wolfgang Walz
    • 1
  1. 1.Department of PhysiologyUniversity of SaskatchewanSaskatoonCanada

Bibliographic information