Principles of Molecular Rheumatology

  • George C. Tsokos

Part of the Current Molecular Medicine book series (CMM, volume 1)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Molecular Mechanisms in Rheumatic Diseases

    1. Front Matter
      Pages 1-1
    2. Peter K. Gregersen
      Pages 3-14
    3. Andras Perl
      Pages 15-33
    4. John D. Mountz, Hui-Chen Hsu, Huang-Ge Zhang, Tong Zhou
      Pages 35-58
    5. Gary S. Gilkeson
      Pages 59-74
    6. Gary A. Koretzky, Erik J. Peterson
      Pages 75-85
    7. Vassiliki A. Boussiotis, Gordon J. Freeman, Lee M. Nadler
      Pages 87-108
    8. Henry K. Wong
      Pages 109-125
    9. Mark H. Wener
      Pages 127-144
    10. V. Michael Holers
      Pages 145-160
    11. Leslie J. Crofford
      Pages 161-173
    12. Sergio A. Jiménez
      Pages 175-196
  3. Cellular Mechanisms in Rheumatic Diseases

    1. Front Matter
      Pages 197-197
    2. Nilamadhab Mishra, Gary M. Kammer
      Pages 199-211
    3. Robert F. Ashman
      Pages 213-223
    4. James M. K. Chan, Sharon M. Wahl
      Pages 225-242
    5. Michael H. Pillinger, Pamela B. Rosenthal, Bruce N. Cronstein
      Pages 243-257
    6. David E. Yocum
      Pages 259-265
    7. Tariq M. Haqqi, Donald D. Anthony, Charles J. Malemud
      Pages 267-277
    8. Stavros C. Manolagas
      Pages 279-291
    9. Thomas J. Lang, Charles S. Via
      Pages 293-308
  4. Pathogenesis of Rheumatic Diseases

    1. Front Matter
      Pages 309-309
    2. Stamatis-Nick C. Liossis, George C. Tsokos
      Pages 311-323
    3. Richard M. Pope, Harris Perlman
      Pages 325-361
    4. Norbert Goebels, Reinhard Hohlfeld
      Pages 363-374
    5. Timothy M. Wright
      Pages 375-383
    6. Jörg J. Goronzy, Cornelia M. Weyand
      Pages 385-399
    7. A. Robin Poole, Ginette Webb
      Pages 401-411
    8. Stavros C. Manolagas
      Pages 413-422
    9. Petros Tsipouras
      Pages 423-436
  5. Molecular Aspects of Treatment of Rheumatic Diseases

    1. Front Matter
      Pages 437-437
    2. Henry K. Wong, George C. Tsokos
      Pages 439-449
    3. David A. Fox, W. Joseph McCune
      Pages 451-464
    4. Savvas C. Makrides
      Pages 465-476
    5. Richard E. Jones, Larry W. Moreland
      Pages 477-486
    6. Woodruff Emlen
      Pages 487-498
    7. Johanne Martel-Pelletier, Ginette Tardif, Julio Fernandes, Jean-Pierre Pelletier
      Pages 499-513
    8. Robert P. Kimberly
      Pages 515-523
  6. Back Matter
    Pages 525-542

About this book


Rheumatic diseases are complex in nature and require for their optimal diagnosis and treatment a critical understanding of the mechanisms that lead to their tissue pathology and various clinical manifestations. In Principles of Molecular Rheumatology, George Tsokos and a panel of authoritative clinicians and researchers synthesize all the latest findings from across cell and molecular biology with the basic principles of rheumatology to create the first textbook of molecular rheumatology. These established experts describe the biochemical mechanisms by which apoptosis, cell signaling, complement, lipids, and viruses contribute to disease expression, and detail both immune and nonimmune cell function in rheumatic diseases. Their review of the major rheumatic diseases integrates the cellular, biochemical, and molecular biological mechanisms that are important in rheumatic disease pathogenesis. The authors also discuss the molecular and cellular mechanisms of action following the administration of the principal drugs used in rheumatology.
Path-breaking and illuminating, Principles of Molecular Rheumatology expands the envelope of clinical understanding to reveal the biological roots underlying rheumatologic disease, as well as the nature and roles of the powerful new therapeutics now emerging for its optimal treatment.


Arthritis osteoarthritis osteoporosis rheumatic diseases rheumatoid arthritis

Editors and affiliations

  • George C. Tsokos
    • 1
    • 2
  1. 1.Walter Reed Army Institute of ResearchSilver SpringUSA
  2. 2.Uniformed Services University of the Health SciencesBethesdaUSA

Bibliographic information