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TRP Channels

Methods and Protocols

  • Antonio Ferrer-Montiel
  • Tim Hucho

Part of the Methods in Molecular Biology book series (MIMB, volume 1987)

Table of contents

  1. Front Matter
    Pages i-x
  2. Pau Doñate-Macián, Alba Crespi-Boixader, Alex Perálvarez-Marín
    Pages 1-21
  3. Appu K. Singh, Luke L. McGoldrick, Alexander I. Sobolevsky
    Pages 23-37
  4. Amrita Samanta, Taylor E. T. Hughes, Vera Y. Moiseenkova-Bell
    Pages 39-50
  5. Verónica I. Dumit, Michael Köttgen, Alexis Hofherr
    Pages 51-64
  6. Celia Cordero-Sánchez, Irene Mudarra-Fraguas, Asia Fernández-Carvajal
    Pages 99-110
  7. Eleonora Zakharian
    Pages 143-166
  8. Osvaldo Alvarez, Karen Castillo, Emerson Carmona, Carlos Gonzalez, Ramon Latorre
    Pages 167-185
  9. Magdalena Nikolaeva Koleva, Gregorio Fernandez-Ballester
    Pages 187-206
  10. Tracey Pirali, Ubaldina Galli, Marta Serafini, Alessia Griglio, Armando A. Genazzani, Gian Cesare Tron
    Pages 207-221
  11. Sara González-Rodríguez
    Pages 223-231
  12. Back Matter
    Pages 233-238

About this book

Introduction

This book aims to provide a guide to researchers on how to work with Transient Receptor Potential (TRP) channels, describing current methodologies and protocols, and highlighting the challenges ahead that will require the development of new technologies. Articles cover a wide range of techniques, from structure to function, concluding with how to best to evaluate some of the in vivo function of TRP channels, particularly in regard to their involvement in hyperalgesia and allodynia. Also, the collection describes important and inspiring available tools that are currently being used to investigate the activity of these channels in vitro and in vivo in terms of their underlying protein structure, segueing into dealing with the generation of pharmacological tools to explore their in vivo activity and their involvement in cellular signaling pathways, which may be developed into drugs to treat diseases caused by channel dysfunction or hyperactivity. Written for the highly successful Methods in Molecular Biology series, chapters include the necessary detail and implementation advice to ensure successful results in the lab. 

Authoritative and practical, TRP Channels: Methods and Protocols is a useful set of methodologies for scientists seeking to better understand this vital family of channels.

Keywords

Transient Receptor Potential channels Non-selective cationic channels Protein structure Pharmacology Therapeutics Cellular signaling pathways Channel dysfunction

Editors and affiliations

  • Antonio Ferrer-Montiel
    • 1
  • Tim Hucho
    • 2
  1. 1.Instituto de Biología, Molecular y CelularUniversidad Miguel HernándezElcheSpain
  2. 2.Experimental Anesthesiology and Pain Research, Department of Anesthesiology and Intensive Care MedicineUniversity Hospital Cologne, University of CologneCologneGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-9446-5
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2019
  • Publisher Name Humana, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-9445-8
  • Online ISBN 978-1-4939-9446-5
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site