Experimental Cholestasis Research

  • Mathieu Vinken

Part of the Methods in Molecular Biology book series (MIMB, volume 1981)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Eva Gijbels, Mathieu Vinken
    Pages 1-14
  3. Debbie Dewaele, Pieter Annaert, Eef Hoeben
    Pages 15-23
  4. Amruta Damle-Vartak, Brigitte Begher-Tibbe, Georgia Gunther, Fabian Geisler, Nachiket Vartak, Jan G. Hengstler
    Pages 25-53
  5. Pieter Van Brantegem, Neel Deferm, Bing Qi, Tom De Vocht, Pieter Annaert
    Pages 55-73
  6. Stef De Lombaerde, Sara Neyt, Christian Vanhove, Filip De Vos
    Pages 87-98
  7. Tânia Sousa, Rui E. Castro, Ana Coutinho, Cecília M. P. Rodrigues, Manuel Prieto, Fábio Fernandes
    Pages 99-115
  8. Benjamin L. Woolbright, Hartmut Jaeschke
    Pages 133-147
  9. Marta B. Afonso, Cecília M. P. Rodrigues
    Pages 149-162
  10. You Li, Ruqui Tang, Patrick S. C. Leung, M. Eric Gershwin, Xiong Ma
    Pages 163-173
  11. Céline Parmentier, Philippe Couttet, Marianne Uteng, Armin Wolf, Lysiane Richert
    Pages 175-186
  12. Johannes P. Schimming, Bas ter Braak, Marije Niemeijer, Steven Wink, Bob van de Water
    Pages 187-202
  13. Noémi Van Hul, Urban Lendahl, Emma R. Andersson
    Pages 203-236
  14. Sanne Van Campenhout, Hans Van Vlierberghe, Lindsey Devisscher
    Pages 237-247
  15. Sujit K. Mohanty, Bryan Donnelly, Haley Temple, Gregory M. Tiao
    Pages 259-271
  16. Duc-Hung Pham, Chunyue Yin
    Pages 273-289
  17. Christiane Guguen-Guillouzo, André Guillouzo
    Pages 291-312
  18. Sreenivasa C. Ramaiahgari, Stephen S. Ferguson
    Pages 313-323
  19. Eva Gijbels, Tamara Vanhaecke, Mathieu Vinken
    Pages 325-333
  20. Neel Deferm, Lysiane Richert, Pieter Van Brantegem, Tom De Vocht, Bing Qi, Peter de Witte et al.
    Pages 335-350
  21. Ruby E. H. Karsten, Dorenda Oosterhuis, Louise A. van Wijk, Peter Olinga
    Pages 351-362
  22. Carol J. Soroka, David N. Assis, James L. Boyer
    Pages 363-372
  23. Fotios Sampaziotis, Olivia Tysoe, Teresa Brevini, Ludovic Vallier
    Pages 373-382
  24. Back Matter
    Pages 397-399

About this book


This detailed book provides a state-of-the-art compilation of protocols relevant for the experimental study of cholestasis, each written by internationally recognized research teams that have built up long-standing expertise regarding one or more aspects of experimental cholestasis research. The first half of the collection examines methods targeted towards studying established and new mechanisms of cholestasis, while the second half explores experimental models and tools to investigate mechanisms of cholestasis and/or to predict cholestatic properties of drugs. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Experimental Cholestasis Research serves as an ideal guide for basic and applied researchers pursuing this vital area of research in pharmacology and toxicology.


Drug-induced liver injury Liver toxicology DILI Cholestatic drug properties Model organisms Impaired bile secretion Hepatocellular injury

Editors and affiliations

  • Mathieu Vinken
    • 1
  1. 1.Department of In Vitro Toxicology and Dermato-CosmetologyVrije Universiteit BrusselBrusselsBelgium

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2019
  • Publisher Name Humana, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-9419-9
  • Online ISBN 978-1-4939-9420-5
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site