Pre-Clinical and Clinical Methods in Brain Trauma Research

1. Front Matter

   Pages i-xiv

   PDF

2. Traumatic Brain Injury

   • Amit K. Srivastava, Charles S. Cox Jr.

   Pages 1-14

3. Three-Dimensional In Vitro Brain Tissue Models

   • Min D. Tang-Schomer

   Pages 15-36

4. Modeling Traumatic Brain Injury In Vitro

   • Daniel E. Bonder, Carolyn E. Keating, Namas Chandra, D. Kacy Cullen, Bryan J. Pfister

   Pages 37-69

5. Drosophila Model to Study Chronic Traumatic Encephalopathy

   • Rojahne Azwoir, Liam Chen

   Pages 71-80

6. Controlled Cortical Impact for Modeling Traumatic Brain Injury in Animals

   • Nicole Osier, C. Edward Dixon

   Pages 81-95

7. Fluid Percussion Model of Traumatic Brain Injury

   • Rachel K. Rowe, Daniel Griffiths, Jonathan Lifshitz

   Pages 97-110

8. Development of a Rodent Model of Closed Head Injury: The Maryland Model

   • Erik Hayman, Kaspar Kaledjian, Vladimir Gerzanich, J. Marc Simard

   Pages 111-121

9. Rodent Model of Primary Blast-Induced Traumatic Brain Injury: Guidelines to Blast Methodology

   • Venkatasivasai Sujith Sajja, Peethambaram Arun, Stephen A. Van Albert, Joseph B. Long

   Pages 123-138

10. Cognitive and Motor Function Assessments in Rodent Models of Traumatic Brain Injury

    • Danielle Scott, Kathryn E. Saatman

    Pages 139-154

11. Pre-Procedural Considerations and Post-Procedural Care for Animal Models with Experimental Traumatic Brain Injury

    • Mary A. Robinson, Samer M. Jaber, Stacey L. Piotrowski, Thomas H. Gomez

    Pages 155-172

12. Laser Capture Microdissection of Single Cells, Cell Populations, and Brain Regions Affected by Traumatic Brain Injury

    • Harris A. Weisz, Deborah R. Boone, Stacy L. Sell, Helen L. Hellmich

    Pages 173-190

13. Rat Microglia Isolation and Characterization Using Multiparametric Panel for Flow Cytometric Analysis

    • Naama E. Toledano Furman, Karthik S. Prabhakara, Supinder Bedi, Charles S. Cox Jr., Scott D. Olson

    Pages 191-199

14. The Principles of Experimental Design and the Determination of Sample Size When Using Animal Models of Traumatic Brain Injury

    • Michael F. W. Festing

    Pages 201-225

15. Advanced Informatics Methods in Acute Brain Injury Research

    • Jude P. J. Savarraj, Mary F. McGuire, Ryan Kitagawa, Huimahn Alex Choi

    Pages 227-242

16. Rapid Detection and Monitoring of Brain Injury Using Sensory-Evoked Responses

    • Jonathan A. N. Fisher, Cristin G. Welle

    Pages 243-256

17. Advanced Neuroimaging Methods in Traumatic Brain Injury

    • Jenifer Juranek

    Pages 257-270

18. Dynamic Contrast-Enhanced MRI for the Analysis of Blood-Brain Barrier Leakage in Traumatic Brain Injury

    • Qiang Shen, Timothy Q. Duong

    Pages 271-282

19. Assessments for Quantifying Neuromotor Functioning After Repetitive Blast Exposure

    • Christopher K. Rhea, Nikita A. Kuznetsov, W. Geoffrey Wright, F. Jay Haran, Scott E. Ross, Josh L. Duckworth

    Pages 283-305

20. Translingual Neurostimulation (TLNS): Perspective on a Novel Approach to Neurorehabilitation after Brain Injury

    • Yuri Danilov, Dafna Paltin

    Pages 307-327

This volume explores current viewpoints and knowledge gaps in the field of traumatic brain injury (TBI). The chapters in this book cover topics ranging from development of in vitro and animal TBI models, to diagnostic imaging and disease monitoring in patients. Designing pre-clinical and clinical trials is also discussed. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.


Practical and thorough, Pre-Clinical and Clinical Methods in Brain Trauma Research is a valuable resource for both scientists and clinical researchers interested in learning about important techniques and their applications in the field of TBI.

• Traumatic brain injury
• In Vitro Traumatic Brain Injury
• Cortical Impact
• Microglial Activation
• Positron Emission Tomography

“This is a well-organized book of neuromethods in brain trauma intended for trainees in the laboratory … . The combination of excellent reviews of experimental procedures, clinical information, and detailed protocols will be helpful for graduate students, postdocs and neurosurgery residents. Additionally, clinicians and clinician scientists involved in translational research should find this volume especially useful.” (Bruce G. Lyeth, Neurosurgery, Vol. 85 (1), July, 2019)

• Department of Pediatric Surgery, McGovern Medical School, The University of Texas Health Sciences Center at Houston, Houston, USA

  Amit K. Srivastava, Charles S. Cox