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Phenotypic Screening

Methods and Protocols

  • Bridget Wagner

Part of the Methods in Molecular Biology book series (MIMB, volume 1787)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Sara S. El Zahed, Garima Kumar, Madeline Tong, Eric D. Brown
    Pages 1-18
  3. Carl J. Balibar, Artjohn Villafania, Christopher M. Barbieri, Nick Murgolo, Terry Roemer, Hao Wang et al.
    Pages 19-40
  4. Nobutaka Kato, Sandra March, Sangeeta N. Bhatia, Matthias Marti
    Pages 41-52
  5. Anna Ngo, Ann Koay, Christian Pecquet, Carmen C. Diaconu, David A. Jenkins, Andrew K. Shiau et al.
    Pages 53-66
  6. Elina Glaubke, Holger Bastians
    Pages 67-75
  7. Courtney A. Ackeifi, Ethan A. Swartz, Peng Wang
    Pages 87-100
  8. Andrea Galmozzi, Christopher G. Parker, Bernard P. Kok, Benjamin F. Cravatt, Enrique Saez
    Pages 115-127
  9. Wenfan Ke, Anna Drangowska-Way, Daniel Katz, Karsten Siller, Eyleen J. O’Rourke
    Pages 129-146
  10. Andrew J. Rennekamp
    Pages 147-159
  11. Taras Pasternak, William Teale, Thorsten Falk, Benedetto Ruperti, Klaus Palme
    Pages 161-170
  12. Scott J. Warchal, John C. Dawson, Neil O. Carragher
    Pages 171-181
  13. Daniela Digles, Andrei Caracoti, Edgar Jacoby
    Pages 183-193
  14. Mark E. Schurdak, Fen Pei, Timothy R. Lezon, Diane Carlisle, Robert Friedlander, D. Lansing Taylor et al.
    Pages 207-222
  15. Jen Q. Pan, David Baez-Nieto, Andrew Allen, Hao-Ran Wang, Jeffrey R. Cottrell
    Pages 235-252
  16. Richard A. Burkhart, Lindsey A. Baker, Hervé Tiriac
    Pages 253-261
  17. Sinéad Knight, Helen Plant, Lisa McWilliams, Mark Wigglesworth
    Pages 263-278
  18. Back Matter
    Pages 279-280

About this book

Introduction

This volume provides a better understanding of the advancements in phenotypic readouts and improved disease models that generate novel biological insights and recapitulate clinically relevant biology. Chapters focus on phenotypic screening, the use of human cell models, microscopic approaches, assays to measure fat accumulation in C. elegans, the threat response in zebrafish, and protein-protein interactions in plant growth and development. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Phenotypic Screening: Methods and Protocols aims to make phenotypic screening approaches more accessible to a wide array of researchers throughout the academic and biotech communities.

Keywords

cancer-cell line profiling Ebola riboswitches C. elegans diabetes

Editors and affiliations

  • Bridget Wagner
    • 1
  1. 1.Chemical Biology and Therapeutics Science ProgramThe Broad Institute of MIT and HarvardCambridgeUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-7847-2
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2018
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-7846-5
  • Online ISBN 978-1-4939-7847-2
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site