Genome Instability

Methods and Protocols

  • Marco Muzi-Falconi
  • Grant W Brown

Part of the Methods in Molecular Biology book series (MIMB, volume 1672)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Carolina A. Novoa, J. Sidney Ang, Peter C. Stirling
    Pages 1-9
  3. Anjana Srivatsan, Christopher D. Putnam, Richard D. Kolodner
    Pages 43-61
  4. Monica Ransom, D. Suzi Bryan, Jay R. Hesselberth
    Pages 63-76
  5. Patrick van Eijk, Yumin Teng, Mark R. Bennet, Katie E. Evans, James R. Powell, Richard M. Webster et al.
    Pages 77-99
  6. Sarah Sertic, Stefania Roma, Paolo Plevani, Federico Lazzaro, Marco Muzi-Falconi
    Pages 101-105
  7. Vincent Pagès, Robert P. Fuchs
    Pages 107-118
  8. Matteo Ferrari, Shyam Twayana, Federica Marini, Achille Pellicioli
    Pages 119-129
  9. Chiara Vittoria Colombo, Luca Menin, Michela Clerici
    Pages 131-145
  10. Pablo Huertas, Andrés Cruz-García
    Pages 147-154
  11. Laura Baranello, Fedor Kouzine, Damian Wojtowicz, Kairong Cui, Keji Zhao, Teresa M. Przytycka et al.
    Pages 155-166
  12. Reza Mirzazadeh, Tomasz Kallas, Magda Bienko, Nicola Crosetto
    Pages 167-194
  13. Xanita Saayman, Cristina Ramos-Pérez, Grant W. Brown
    Pages 195-207
  14. Andrea Keszthelyi, Izumi Miyabe, Katie Ptasińska, Yasukazu Daigaku, Karel Naiman, Antony M. Carr
    Pages 239-259

About this book


This volume presents forty-two methods and protocols to analyze diverse aspects of genome instability. Chapters detail mutagenesis and repair, methods to quantify and analyze the properties of DNA double-strand breaks, profile replication, replication proteins strand-specifically, genome instability, fluorescence microscopic techniques, and genomic and proteomic approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Genome Instability: Methods and Protocols aims to provide a comprehensive resource for the discovery and analysis of the proteins and pathways that are critical for stable maintenance of the genome.


eukaryotes telomere maintenance yeast stem cell renewal cancer biology

Editors and affiliations

  • Marco Muzi-Falconi
    • 1
  • Grant W Brown
    • 2
  1. 1.Dipartimento di BioscienzeUniversità degli Studi di MilanoMilanoItaly
  2. 2.Donnelly Centre and Department of BiochemistryUniversity of TorontoTorontoCanada

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media LLC 2018
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-7305-7
  • Online ISBN 978-1-4939-7306-4
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • About this book