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Proteomics for Drug Discovery

Methods and Protocols

  • Book
  • © 2017


  • Includes cutting-edge techniques for the study of drug discovery via proteomics
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1647)

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Table of contents (20 protocols)


About this book

This book reflects the drug development community’s interest in proteomics methods by providing researchers with the necessary knowledge for the implementation of a number of basic experimental and bioinformatics protocols in the drug discovery research laboratory. The focus of the collection is on select protocols and methodologies that address the analysis of post-translational modifications, targeted protein quantification, protein-protein, protein-lipid, or protein-ATP interactions, in silico lead identification, protein arrays, tissue and cell extract preparation, labeling, chemoproteomics, and drug efficacy assessment. Emphasis was placed not just on methods that describe large-scale protein analysis, but also on ones that are amenable to future implementation in a high-throughput format. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Practical and authoritative, Proteomics for Drug Discovery: Methods and Protocols aims to provide a deep knowledge of the fundamentals of disease biology as well the means that were developed for probing the complex biological milieu.

Editors and Affiliations

  • Department of Biological Sciences, Virginia Tech, Blacksburg, USA

    Iulia M. Lazar

  • Department of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville, Edwardsville, USA

    Maria Kontoyianni

  • ImmunoGen, Waltham, USA

    Alexandru C. Lazar

Bibliographic Information

  • Book Title: Proteomics for Drug Discovery

  • Book Subtitle: Methods and Protocols

  • Editors: Iulia M. Lazar, Maria Kontoyianni, Alexandru C. Lazar

  • Series Title: Methods in Molecular Biology

  • DOI:

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media LLC 2017

  • Hardcover ISBN: 978-1-4939-7200-5Published: 15 August 2017

  • Softcover ISBN: 978-1-4939-8414-5Published: 03 August 2018

  • eBook ISBN: 978-1-4939-7201-2Published: 14 August 2017

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XI, 302

  • Number of Illustrations: 16 b/w illustrations, 46 illustrations in colour

  • Topics: Pharmacology/Toxicology

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