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  • © 2017

Multiparticulate Drug Delivery

Formulation, Processing and Manufacturing

Editors:

(view affiliations)
  • Comprehensive update on new and emerging approaches in the design of multiparticulate dosage forms

  • Covers the opportunities and hidden challenges that arise during formulation

  • Scale-up and manufacture Features case studies illustrating best practices

  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Delivery Science and Technology (ADST)

Buying options

eBook
USD 169.00
Price excludes VAT (USA)
  • ISBN: 978-1-4939-7012-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 219.99
Price excludes VAT (USA)
Hardcover Book
USD 219.99
Price excludes VAT (USA)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xii
  2. Characterization of Inert Cores for Multiparticulate Dosage Forms

    • Richard Sidwell, Jason Hansell, Manish Rane, Ali R. Rajabi-Siahboomi
    Pages 5-35
  3. The Science and Practice of Extrusion-Spheronization

    • Markus Thommes, Peter Kleinebudde
    Pages 37-63
  4. Fluid Bed Technology, Process Robustness, and Scale-Up

    • David M. Jones, Ali R. Rajabi-Siahboomi
    Pages 65-93
  5. Mini-tabs: Versatile Multiparticulate Option for Oral Drug Delivery

    • Marina Levina, Hue Voung, Ali R. Rajabi-Siahboomi
    Pages 95-118
  6. Science and Practice of Microencapsulation Technology

    • Sandile M. M. Khamanga, Roderick B. Walker
    Pages 119-154
  7. Multiparticulate Technologies for Fixed-Dose Combinations

    • W. Brett Caldwell, Aditya M. Kaushal
    Pages 155-168
  8. Multiparticulate Systems for Paediatric Drug Delivery

    • Affiong Iyire, Afzal R. Mohammed
    Pages 213-236
  9. Application of Poly(meth)acrylate Copolymers for Oral Multiparticulate Drug Delivery Systems

    • Theresia Kuntz, Wolfgang Weisbrod, Subhashis Chakraborty, Brigitte Skalsky
    Pages 237-266
  10. Ethylcellulose Applications in Multiparticulate Systems

    • Ali R. Rajabi-Siahboomi, Raxit Y. Mehta, Vaibhav Ambudkar, Viena Dias, Sandip Tiwari
    Pages 267-299
  11. In-Line Particle Size Characterization of Multiparticulate Systems

    • Stefan Dietrich, Dieter Petrak
    Pages 301-332
  12. Back Matter

    Pages 387-396

About this book

Authored by leading experts from academia, users and manufacturers, this book provides an authoritative account of the science and technology involved in multiparticulate drug delivery systems which offer superior clinical and technical advantages over many other specialized approaches in drug delivery. The book will cover market trends, potential benefits and formulation challenges for various types of multiparticulate systems. Drug solubility, dose, chemistry and therapeutic indications as well as excipient suitability coupled with manufacturing methods will be fully covered. Key approaches for taste-masking, delayed release and extended release of multiparticulates systems are of significant interest, especially their in-vivo and in-vitro performance. In addition, the principles of scale-up, QbD, and regulatory aspects of common materials used in this technology will be explained, as well as recent advances in materials and equipment enabling robust, flexible and cost-effective manufacture. Case studies illustrating best practices will also make the book a valuable resource to pharmaceutical scientists in industry and academia.

Keywords

  • Dissolution
  • Drug Delivery
  • Multiparticulate
  • Pellets
  • Scale-up

Editors and Affiliations

  • VP & Chief Scientific Officer, Colorcon Inc., Harleysville, USA

    Ali R. Rajabi-Siahboomi

About the editor

Ali Rajabi-Siahboomi is Vice President and Chief Scientific Officer at Colorcon Inc. He obtained his PhD in Pharmacy from University of Nottingham (UK). Dr. Rajabi-Siahboomi held various academic positions in Nottingham and Liverpool JM Universities (UK), before joining Colorcon. His main research interests are in the area of solid dosage form pharmaceutics and pharmaceutical technology with emphasis on oral drug delivery systems. He has published over 150 articles, book chapters, abstracts and patents.

Bibliographic Information

  • Book Title: Multiparticulate Drug Delivery

  • Book Subtitle: Formulation, Processing and Manufacturing

  • Editors: Ali R. Rajabi-Siahboomi

  • Series Title: Advances in Delivery Science and Technology

  • DOI: https://doi.org/10.1007/978-1-4939-7012-4

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2017

  • Hardcover ISBN: 978-1-4939-7010-0

  • Softcover ISBN: 978-1-4939-8367-4

  • eBook ISBN: 978-1-4939-7012-4

  • Series ISSN: 2192-6204

  • Series E-ISSN: 2192-6212

  • Edition Number: 1

  • Number of Pages: XII, 396

  • Number of Illustrations: 56 b/w illustrations, 100 illustrations in colour

  • Topics: Pharmaceutics

Buying options

eBook
USD 169.00
Price excludes VAT (USA)
  • ISBN: 978-1-4939-7012-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 219.99
Price excludes VAT (USA)
Hardcover Book
USD 219.99
Price excludes VAT (USA)