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Stem Cell-Derived Models in Toxicology

  • Mike Clements
  • Liz Roquemore

Part of the Methods in Pharmacology and Toxicology book series (MIPT)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Alison Obergrussberger, Claudia Haarmann, Sonja Stölzle-Feix, Nadine Becker, Atsushi Ohtsuki, Andrea Brüggemann et al.
    Pages 57-82
  3. Emily R. Pfeiffer, Ross Whittaker, Raquel Vega, Fabio Cerignoli, Patrick M. McDonough, Jeffrey H. Price
    Pages 153-171
  4. Alison Obergrussberger, Ulrich Thomas, Sonja Stölzle-Feix, Nadine Becker, Krisztina Juhasz, Leo Doerr et al.
    Pages 191-209
  5. Carlota Oleaga, Gregg Legters, L. Richard Bridges, Lee Kumanchik, Candace Martin, Yunqing Cai et al.
    Pages 229-246
  6. Liz Roquemore, M. Ariel Kauss, Catherine Hather, Nick Thomas, Hirdesh Uppal
    Pages 247-269
  7. Janos Kriston-Vizi, Sian E. Harding, Gábor Földes
    Pages 271-291
  8. Udo Kraushaar, Elke Guenther, Dietmar Hess
    Pages 293-309
  9. Back Matter
    Pages 335-341

About this book

Introduction

This detailed volume brings together a diverse collection of stem cell-derived model-based toxicity assays, from those routinely used to those deemed to have considerable potential. With a focus on differentiated tissues, the chapters explore numerous cardiotoxicity applications as well as coverage of neurotoxicity, hepatotoxicity, and more. Written for the Methods in Pharmacology and Toxicology series, the contents of this book aim to enable adoption of these protocols in laboratories that are interested in entering the field as well as to facilitate the transfer of best practices between laboratories that are already actively pursuing these technologies. 

Authoritative and cutting-edge, Stem Cell-Derived Models in Toxicology serves as a vital resource for researchers aiming to improve risk assessment in drug discovery and design.

Keywords

Cardiotoxicity Cardiomyocytes Hepatotoxicity Neurotoxicity Pluripotent stem cell models Drug development Pre-clinical safety assessments

Editors and affiliations

  • Mike Clements
    • 1
  • Liz Roquemore
    • 2
  1. 1.Axion BioSystems, Inc.AtlantaUSA
  2. 2.Cell ApplicationsGE HealthcareCardiffUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-6661-5
  • Copyright Information Springer Science+Business Media New York 2017
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-6659-2
  • Online ISBN 978-1-4939-6661-5
  • Series Print ISSN 1557-2153
  • Series Online ISSN 1940-6053
  • Buy this book on publisher's site