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  • © 2017

Computational Protein Design

Editors:

  • Includes cutting-edge methods and protocols

  • Provides step-by-step detail essential for reproducible results

  • Contains key notes and implementation advice from the experts

  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Molecular Biology (MIMB, volume 1529)

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eBook USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-1-4939-6637-0
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 139.99
Price excludes VAT (USA)
Hardcover Book USD 199.99
Price excludes VAT (USA)

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Table of contents (23 protocols)

  1. Computational Protein Design of Specific Targets

    1. A Protocol for the Design of Protein and Peptide Nanostructure Self-Assemblies Exploiting Synthetic Amino Acids

      • Nurit Haspel, Jie Zheng, Carlos Aleman, David Zanuy, Ruth Nussinov
      Pages 323-352
    2. Probing Oligomerized Conformations of Defensin in the Membrane

      • Wenxun Gan, Dina Schneidman, Ning Zhang, Buyong Ma, Ruth Nussinov
      Pages 353-362
    3. Computational Design of Ligand Binding Proteins

      • Christine E. Tinberg, Sagar D. Khare
      Pages 363-373
    4. EpiSweep: Computationally Driven Reengineering of Therapeutic Proteins to Reduce Immunogenicity While Maintaining Function

      • Yoonjoo Choi, Deeptak Verma, Karl E. Griswold, Chris Bailey-Kellogg
      Pages 375-398
    5. Computational Tools for Aiding Rational Antibody Design

      • Konrad Krawczyk, James Dunbar, Charlotte M. Deane
      Pages 399-416
    6. Computational Design of Membrane Curvature-Sensing Peptides

      • Armando Jerome de Jesus, Hang Yin
      Pages 417-437
  2. Back Matter

    Pages 447-450

About this book

The aim this volume is to present the methods, challenges, software, and applications of this widespread and yet still evolving and maturing field. Computational Protein Design, the first book with this title, guides readers through computational protein design approaches, software and tailored solutions to specific case-study targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Computational Protein Design aims to ensure successful results in the further study of this vital field.

Keywords

  • designed protein
  • Dead-End-Elimination (DEE)
  • protein-protein complexes
  • molecular dynamics
  • normal mode analysis
  • drug-resistance mutations
  • symmetric proteins
  • synthetic amino acids

Editors and Affiliations

  • Department of Plants and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel

    Ilan Samish

Bibliographic Information

  • Book Title: Computational Protein Design

  • Editors: Ilan Samish

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-6637-0

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2017

  • Hardcover ISBN: 978-1-4939-6635-6

  • Softcover ISBN: 978-1-4939-8256-1

  • eBook ISBN: 978-1-4939-6637-0

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XII, 450

  • Number of Illustrations: 33 b/w illustrations, 111 illustrations in colour

  • Topics: Protein Biochemistry

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-1-4939-6637-0
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 139.99
Price excludes VAT (USA)
Hardcover Book USD 199.99
Price excludes VAT (USA)