Protein Tyrosine Phosphatases in Cancer

  • Benjamin G. Neel
  • Nicholas K. Tonks

Table of contents

  1. Front Matter
    Pages i-viii
  2. Andrew W. Stoker
    Pages 13-45
  3. Wiljan J. A. J. Hendriks, Frank-D Böhmer
    Pages 47-113
  4. Gordon Chan, Benjamin G. Neel
    Pages 115-143
  5. Tony Tiganis
    Pages 145-168
  6. David P. Labbé, Michel L. Tremblay
    Pages 169-199
  7. Dawid G. Nowak, Lloyd C. Trotman
    Pages 233-246
  8. Antonella Papa, Pier Paolo Pandolfi
    Pages 247-260
  9. Cameron A. Rogers, Catherine J. Pallen
    Pages 261-282
  10. Brian Gabrielli, Andrew Burgess
    Pages 283-306
  11. Rongjun He, Zhong-Yin Zhang
    Pages 335-353
  12. Back Matter
    Pages 355-360

About this book

Introduction

This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts.

Protein Tyrosine Phosphatases in Cancer,from renowned researchers Benjamin Neel and Nicholas Tonks, is invaluable reading for researchers in oncology, stem cell signaling,and biochemistry. 

Keywords

Phosphatase SHP2 TC-PTP PTEN CdC25

Editors and affiliations

  • Benjamin G. Neel
    • 1
  • Nicholas K. Tonks
    • 2
  1. 1.Laura and Isaac Perlmutter Cancer CenterNYUSA
  2. 2.Cold Spring Harbor LaboratoryCold Spring HarborUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-3649-6
  • Copyright Information Springer Science+Business Media, LLC 2016
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4939-3647-2
  • Online ISBN 978-1-4939-3649-6
  • About this book