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  • © 2016

Immunotherapy and Biomarkers in Neurodegenerative Disorders

  • Includes cutting-edge techniques for the study of neurodegenerative disorders through immunotherapy and biomarker research

  • Offers state-of-the-art contributions from renowned experts

  • Features practical and vital implementation advice

  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Pharmacology and Toxicology (MIPT)

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-1-4939-3560-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 139.99
Price excludes VAT (USA)
Hardcover Book USD 169.99
Price excludes VAT (USA)

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Table of contents (16 protocols)

  1. Front Matter

    Pages i-x
  2. Immunotherapy Against Amyloid-β in Alzheimer’s Disease

    1. Front Matter

      Pages 1-1
    2. Active Immunization Against the Amyloid-β Peptide

      • Enchi Liu, J. Michael Ryan
      Pages 19-35
    3. Immunotherapy Against N-Truncated Amyloid-β Oligomers

      • Thomas A. Bayer, Oliver Wirths
      Pages 37-50
  3. Immunotherapy in Other Neurodegenerative Disorders

    1. Front Matter

      Pages 61-61
    2. Immunotherapy Against α-Synuclein Pathology

      • Elvira Valera, Eliezer Masliah
      Pages 63-72
    3. Extracellular α-Synuclein as a Target for Immunotherapy

      • Jun Sung Lee, Seung-Jae Lee
      Pages 73-83
    4. Immunotherapy of Parkinson’s Disease

      • Achim Schneeberger, Suzanne Hendrix, Markus Mandler
      Pages 85-108
    5. Tau Immunotherapy

      • Einar M. Sigurdsson
      Pages 109-120
    6. Active and Passive Immunotherapy Against Tau: Effects and Potential Mechanisms

      • Kiran Yanamandra, Marc I. Diamond, David M. Holtzman
      Pages 121-138
  4. Biomarkers for Neurodegenerative Disorders

    1. Front Matter

      Pages 151-151
    2. Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease

      • Henrik Zetterberg, Jonathan M. Schott
      Pages 153-179
    3. Volumetric MRI as a Diagnostic Tool in Alzheimer’s Disease

      • Eric Westman, Lena Cavalin, Lars-Olof Wahlund
      Pages 181-198
    4. Alpha-Synuclein as a Diagnostic Biomarker for Parkinson’s Disease

      • Joakim Bergström, Martin Ingelsson
      Pages 215-234
    5. Imaging as a Diagnostic Tool in Parkinson’s Disease

      • Johan Wikström, Torsten Danfors
      Pages 235-252
    6. Mass Spectrometry-Based Proteomics in Biomarker Discovery for Neurodegenerative Diseases

      • Sravani Musunuri, Ganna Shevchenko, Jonas Bergquist
      Pages 253-282

About this book

This practical volume examines a number of topics that explore the current status of immunotherapy and diagnostic markers for neurodegenerative disorders. With a focus on Alzheimer’s disease, the first sections of the book examine immunotherapeutic approaches for the aforementioned disease as well as for Parkinson’s disease and Huntington’s disease, amongst others. The last section of the book covers the importance of biomarker techniques to catch these diseases early enough for the treatments to be most useful. Written for the Methods in Pharmacology and Toxicology series, this book contains the kind of detailed descriptions and implementation advice that will offer a smooth transition into the lab.

Authoritative and useful, Immunotherapy and Biomarkers in Neurodegenerative Disorders aims to aid in the continued progress in the development of novel immune-based drugs and diagnostic tools for these devastating brain diseases.

Keywords

  • Amyloid-Beta
  • Alzheimer’s Disease
  • Αlpha-Synuclein
  • Tau protein
  • Therapeutic antibodies
  • Monoclonal antibodies
  • Immunotherapeutic targets
  • Parkinson’s disease

Editors and Affiliations

  • Dept Public Health & Caring Sci Ger, Uppsala University, Uppsala, Sweden

    Martin Ingelsson, Lars Lannfelt

Bibliographic Information

  • Book Title: Immunotherapy and Biomarkers in Neurodegenerative Disorders

  • Editors: Martin Ingelsson, Lars Lannfelt

  • Series Title: Methods in Pharmacology and Toxicology

  • DOI: https://doi.org/10.1007/978-1-4939-3560-4

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2016

  • Hardcover ISBN: 978-1-4939-3558-1Published: 14 April 2016

  • Softcover ISBN: 978-1-4939-8078-9Published: 19 April 2018

  • eBook ISBN: 978-1-4939-3560-4Published: 13 April 2016

  • Series ISSN: 1557-2153

  • Series E-ISSN: 1940-6053

  • Edition Number: 1

  • Number of Pages: X, 289

  • Number of Illustrations: 8 b/w illustrations, 32 illustrations in colour

  • Topics: Pharmacology

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-1-4939-3560-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 139.99
Price excludes VAT (USA)
Hardcover Book USD 169.99
Price excludes VAT (USA)