Skip to main content
  • Book
  • © 2016

Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture

  • Provides a practical introduction to the current state of the art in modeling and simulation of pharmaceutical processes

  • Explores methodologies in drug product development

  • Features expert tips and implementation advice for application in the lab

  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Pharmacology and Toxicology (MIPT)

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 139.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

This is a preview of subscription content, log in via an institution to check for access.

Table of contents (10 protocols)

  1. Front Matter

    Pages i-x
  2. Applications of Modeling in Oral Solid Dosage Form Development and Manufacturing

    • Olav Lyngberg, Lieve Bijnens, Jeroen Geens, Alex Marchut, Steve Mehrman, Elisabeth Schafer
    Pages 1-42
  3. Population Balance Models for Pharmaceutical Processes

    • Anwesha Chaudhury, Maitraye Sen, Dana Barrasso, Rohit Ramachandran
    Pages 43-83
  4. A Quantitative Approach to Understand Raw Material Variability

    • Sara Koynov, Fernando J. Muzzio
    Pages 85-104
  5. Discrete Element Modeling of Solid Dosage Manufacturing Processes

    • Dana Barrasso, Rohit Ramachandran
    Pages 105-131
  6. A Procedure for Developing Quantitative Near Infrared (NIR) Methods for Pharmaceutical Products

    • Rodolfo J. Romañach, Andrés D. Román-Ospino, Manel Alcalà
    Pages 133-158
  7. Advanced Process Decision Making Using Multivariate Latent Variable Methods

    • Matteo Ottavian, Emanuele Tomba, Massimiliano Barolo
    Pages 159-189
  8. Advanced Control of Continuous Pharmaceutical Tablet Manufacturing Processes

    • Ravendra Singh, Carlos Velazquez, Abhishek Sahay, Krizia M. Karry, Fernando J. Muzzio, Marianthi G. Ierapetritou et al.
    Pages 191-224
  9. Mathematical Tools for the Quantitative Definition of a Design Space

    • Amanda Rogers, Marianthi G. Ierapetritou
    Pages 225-279
  10. Optimization Methodologies for the Production of Pharmaceutical Products

    • M. Sebastian Escotet-Espinoza, Amanda Rogers, Marianthi G. Ierapetritou
    Pages 281-309
  11. An Overview of Pharmaceutical Manufacturing for Solid Dosage Forms

    • Stephan Sacher, Johannes G. Khinast
    Pages 311-383
  12. Back Matter

    Pages 385-393

About this book

This thorough volume aims to provide pharmaceutical engineers with an introduction to the current state of the art in modeling and simulation of pharmaceutical processes and to summarize a number of practical applications of relevant methodologies in drug product development. Chapters include explorations of simulation and modeling methodologies, data collection and analysis, development of novel sensing techniques, development and integration of individual unit models, optimization approaches for data-based models, design space evaluation techniques, informatics-based methodologies, and emerging topics in pharmaceutical process development. As a part of the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and implementation advice that will make the transition into the laboratory as smooth as possible.

Authoritative and cutting edge, Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture seeks to promote research into process systems methodologies and their application in pharmaceutical product and process development, which will undoubtedly become an increasingly important area in the future.

Editors and Affiliations

  • Rutgers University, Piscataway, USA

    Marianthi G. Ierapetritou, Rohit Ramachandran

Bibliographic Information

  • Book Title: Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture

  • Editors: Marianthi G. Ierapetritou, Rohit Ramachandran

  • Series Title: Methods in Pharmacology and Toxicology

  • DOI: https://doi.org/10.1007/978-1-4939-2996-2

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2016

  • Hardcover ISBN: 978-1-4939-2995-5Published: 02 October 2015

  • Softcover ISBN: 978-1-4939-4996-0Published: 23 August 2016

  • eBook ISBN: 978-1-4939-2996-2Published: 30 September 2015

  • Series ISSN: 1557-2153

  • Series E-ISSN: 1940-6053

  • Edition Number: 1

  • Number of Pages: X, 393

  • Number of Illustrations: 35 b/w illustrations, 96 illustrations in colour

  • Topics: Pharmacology/Toxicology

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 139.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access