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Nucleic Acid Crystallography

Methods and Protocols

  • Book
  • © 2016


  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1320)

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About this book

This volume includes comprehensive and up-to-date coverage of all nucleic-acid-specific steps used in X-ray crystallography, from macromolecule production to structure determination. Chapters dedicated to RNA preparation and crystallogenesis will be of interest to beginners, while chapters focused on data collection, phasing and refinement will be particularly useful to researchers with a higher level of expertise. Several functional case studies are also presented in the last part of the book. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and thorough, Nucleic Acid Crystallography: Methods and Protocols presents protocols that are aimed at both researchers and students who are interested in the structural biology of DNA or RNA, alone or in complex with proteins or ligands.

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Table of contents (22 protocols)

  1. Introduction

  2. RNA Preparation and Crystallogenesis

  3. Data Collection, Phasing and Refinement

Editors and Affiliations

  • CNRS Inst de Biol Moléculaire et Cellulaire, Strasbourg, France

    Eric Ennifar

About the editor

Eric Ennifar Institut de Biologie Moléculaire et Cellulaire du CNRS 15 Rue René Descartes F-67084 Strasbourg, France +33 (0)3 88 41 70 02 email:

Bibliographic Information

  • Book Title: Nucleic Acid Crystallography

  • Book Subtitle: Methods and Protocols

  • Editors: Eric Ennifar

  • Series Title: Methods in Molecular Biology

  • DOI:

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2016

  • Hardcover ISBN: 978-1-4939-2762-3Published: 31 July 2015

  • Softcover ISBN: 978-1-4939-4641-9Published: 19 October 2016

  • eBook ISBN: 978-1-4939-2763-0Published: 30 July 2015

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XI, 356

  • Number of Illustrations: 18 b/w illustrations, 98 illustrations in colour

  • Topics: Nucleic Acid Chemistry

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