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Label-Free Biosensor Methods in Drug Discovery

  • Ye Fang

Part of the Methods in Pharmacology and Toxicology book series (MIPT)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Review

    1. Front Matter
      Pages 1-1
    2. S. Nicole Davidoff, Noah T. Ditto, Amanda E. Brooks, Josh Eckman, Benjamin D. Brooks
      Pages 35-76
    3. Jie Zhou, Xianxin Qiu, Ping Wang
      Pages 77-108
  3. Biochemical Profiling and Screening

    1. Front Matter
      Pages 109-109
    2. Muzammil Iqbal, Rufus W. Burlingame, Randy Romero, Annabel Wang, Tyler Grove, Martin A. Gleeson
      Pages 133-153
  4. Cell Phenotypic Profiling and Screening

    1. Front Matter
      Pages 167-167
    2. Douglas G. Tilley, Ashley A. Repas, Rhonda L. Carter
      Pages 169-182
    3. Philippe Bourassa, Thomas Söllradl, Jean-Sébastien Maltais, Paul G. Charette, Louis Gendron, Michel Grandbois
      Pages 183-195
    4. Hannah J. Gitschier, Audrey B. Bergeron, David H. Randle, Caryn E. Bacon, Melvyn Baez, Peiyi Yang et al.
      Pages 197-214
    5. Xinmiao Liang, Jixia Wang, Xiuli Zhang, Ye Fang
      Pages 233-252
    6. Filomain Nguemo, Judith Semmler, Jürgen Hescheler
      Pages 283-305
    7. Benjamin Rappaz, Fabien Kuttler, Billy Breton, Gerardo Turcatti
      Pages 307-325
    8. Norbert Orgovan, Beatrix Peter, Szilvia Bősze, Jeremy J. Ramsden, Bálint Szabó, Robert Horvath
      Pages 327-338
    9. Ridha Limame, Olivier De Wever
      Pages 339-351
    10. Yuhki Yanase, Michihiro Hide
      Pages 373-385
  5. Back Matter
    Pages 387-390

About this book

Introduction

This volume explores label-free biosensors, advantageous in part because this technology bypasses the need of labels, reporters, and cell engineering, all of which are common to labeled techniques but may introduce artifacts in assay results. Addressing several fundamental and practical aspects as to how to implement label-free methods in the drug discovery process, this book covers a wide range of topics, including binding kinetics determination, fragment screening, antibody epitope mapping, protein-protein interaction profiling and screening, receptor pathway deconvolution, drug pharmacology profiling and screening, target identification, drug toxicity assessment, and physical phenotype profiling and diagnostics based on various cellular processes such as cell adhesion, migration, invasion, infection, and inflammation. As part of the Methods in Pharmacology and Toxicology series, chapters aim to provide key detail and implementation advice to aid with progress in the lab.

Practical and thorough, Label-Free Biosensor Methods in Drug Discovery provides a new avenue for rapid access to a focused collection of highly regarded contributions in the field.

Keywords

Biotechnology Cell signaling Clinical diagnostics Drug safety assessment Drug screening and profiling Drug-target binding Hit identification Lead optimization Probe discovery Target engagement determination

Editors and affiliations

  • Ye Fang
    • 1
  1. 1.Biochemical Technologies, Science and Technology DivisionCorning IncorporatedCorningUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-2617-6
  • Copyright Information Springer Science+Business Media New York 2015
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-2616-9
  • Online ISBN 978-1-4939-2617-6
  • Series Print ISSN 1557-2153
  • Series Online ISSN 1940-6053
  • Buy this book on publisher's site