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Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease

  • Deric L. Wheeler
  • Yosef Yarden

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Manfred Schartl, Jean-Nicolas Volff, Frederic Brunet
    Pages 17-36
  3. Yi Du, Jennifer L. Hsu, Ying-Nai Wang, Mien-Chie Hung
    Pages 77-109
  4. Yehoshua Enuka, Morris E. Feldman, Yosef Yarden
    Pages 111-132
  5. Alexander Sorkin, Arola Fortian
    Pages 133-161
  6. Michael C. Lawrence, Colin W. Ward
    Pages 163-193
  7. Dániel Süveges, Natalia Jura
    Pages 195-223
  8. Wolfgang J. Köstler, Christoph C. Zielinski
    Pages 225-278
  9. Martin Holcmann, Nicole Amberg, Barbara Drobits, Elisabeth Glitzner, Karin Komposch, Jonathan Robson et al.
    Pages 279-438
  10. Back Matter
    Pages 439-440

About this book

Introduction

Receptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade have become the number one targets of cancer drugs. Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease systematically covers, for the first time, the shared structural and functional features of the RTK family. Understanding the evolutionary origin of the 58 RTKs, their roles in invertebrates and in humans, as well as downstream signaling pathways, is essential for fundamental research and for attempts to develop pharmacological agents able to enhance or intercept their actions. The assembly of chapters written by experts underscores commonalities and is an ideal companion volume to The Receptor Tyrosine Kinase Family, which refers to specific subfamilies of RTKs, along with their unique landmarks.

Keywords

Kinase Proteins Receptors Signaling pathways Tyrosines

Editors and affiliations

  • Deric L. Wheeler
    • 1
  • Yosef Yarden
    • 2
  1. 1.Department of Human OncologyUniversity of WisconsinMadisonUSA
  2. 2.Department of Biological RegulationWeizmann Institute of ScienceRehovotIsrael

Bibliographic information