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  • © 2015

Peptide Libraries

Methods and Protocols

Editors:

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  • Includes cutting-edge methods and protocols

  • Provides step-by-step detail essential for reproducible results

  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1248)

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USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-1-4939-2020-4
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  • Tax calculation will be finalised during checkout
Softcover Book
USD 139.99
Price excludes VAT (USA)
Hardcover Book
USD 179.99
Price excludes VAT (USA)

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Table of contents (18 protocols)

  1. Front Matter

    Pages i-xvii
  2. Chemical Strategies for Library Synthesis

    1. Front Matter

      Pages 1-1
    2. Design, Synthesis, and Application of OB2C Combinatorial Peptide and Peptidomimetic Libraries

      • Ruiwu Liu, Tsung-Chieh Shih, Xiaojun Deng, Lara Anwar, Sara Ahadi, Pappanaicken Kumaresan et al.
      Pages 3-22
    3. Synthesis and Screening of One-Bead-One-Compound Cyclic Peptide Libraries

      • Ziqing Qian, Punit Upadhyaya, Dehua Pei
      Pages 39-53
    4. Macrocyclic Templates for Library Synthesis of Peptido-Conjugates

      • Serge Zaretsky, Joanne Tan, Jennifer L. Hickey, Andrei K. Yudin
      Pages 67-80
  3. Chemistry and Genetically-Encoded Peptide Libraries

    1. Front Matter

      Pages 93-93
    2. A Fragment-Based Selection Approach for the Discovery of Peptide Macrocycles Targeting Protein Kinases

      • Elizabeth Restituyo, Karla Camacho-Soto, Indraneel Ghosh
      Pages 95-104
    3. Peptide and Peptide Library Cyclization via Bromomethylbenzene Derivatives

      • David E. Hacker, Mohammed Almohaini, Aruna Anbazhagan, Zhong Ma, Matthew C. T. Hartman
      Pages 105-117
    4. Phage Selection of Bicyclic Peptides Based on Two Disulfide Bridges

      • Shiyu Chen, Christian Heinis
      Pages 119-137
    5. Chemical Posttranslational Modification of Phage-Displayed Peptides

      • Simon Ng, Katrina F. Tjhung, Beth M. Paschal, Christopher J. Noren, Ratmir Derda
      Pages 155-172
    6. Identifying Reactive Peptides from Phage-Displayed Libraries

      • Glenn M. Eldridge, Gregory A. Weiss
      Pages 189-199
  4. Utility of Peptide Libraries

    1. Front Matter

      Pages 221-221
    2. Synthesis and Cell-Based Screening of One-Bead-One-Compound Peptide Libraries

      • Fernanda C. Bononi, Leonard G. Luyt
      Pages 223-237
    3. Screening Peptide Array Library for the Identification of Cancer Cell-Binding Peptides

      • Kamaljit Kaur, Sahar Ahmed, Rania Soudy, Sarfuddin Azmi
      Pages 239-247

About this book

This volume provides an overview of modern and emerging methods for production, analysis,  and utility of peptide libraries. Chapter focus on methods and techniques for synthesis, genetic expression, hybrid synthesis-expression, examples of modern utility of these libraries, de novo discovery of reactions,  hybrid organic-inorganic materials and, emerging tools for the analysis of these libraries by method of genetic selection and next-generation sequencing. Written in the highly successful Methods in Molecular Biology  series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 

Authoritative and practical, Peptide Libraries: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies.

Keywords

  • combinatorial peptide
  • cyclic peptides
  • isopeptide linkages
  • library synthesis
  • peptide libraries
  • peptidomimetic libraries

Editors and Affiliations

  • Dept of Chemistry, University of Alberta, Edmonton, Canada

    Ratmir Derda

Bibliographic Information

  • Book Title: Peptide Libraries

  • Book Subtitle: Methods and Protocols

  • Editors: Ratmir Derda

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-2020-4

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2015

  • Hardcover ISBN: 978-1-4939-2019-8

  • Softcover ISBN: 978-1-4939-4642-6

  • eBook ISBN: 978-1-4939-2020-4

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XVII, 278

  • Number of Illustrations: 45 b/w illustrations, 42 illustrations in colour

  • Topics: Protein Biochemistry

Buying options

eBook
USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-1-4939-2020-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 139.99
Price excludes VAT (USA)
Hardcover Book
USD 179.99
Price excludes VAT (USA)