Receptor Tyrosine Kinases

Methods and Protocols

  • Serena Germano

Part of the Methods in Molecular Biology book series (MIMB, volume 1233)

Table of contents

  1. Front Matter
    Pages i-xi
  2. RTKs Activation and Signalling

  3. RTKs Aberrant Expression

    1. Front Matter
      Pages 65-65
    2. Diana Boehm, Anne von Mässenhausen, Sven Perner
      Pages 67-79
  4. RTKs Trafficking and Negative Regulation

  5. RTKs as Pharmacological Targets

    1. Front Matter
      Pages 149-149
    2. Susan Breslin, Lorraine O’Driscoll
      Pages 161-168

About this book

Introduction

Receptor Tyrosine Kinases: Methods and Protocols explores on the most widely studied of the protein classes, known for their central role in several cellular functions and in a variety of human pathologies. Beginning with a section on activation and signaling of Receptor Tyrosine Kinases (RTKs), the book continues with chapters on aberrant expression of RTKs, trafficking and negative regulation, as well as RTKs as pharmacological targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Receptor Tyrosine Kinases: Methods and Protocols contains an up-to-date overview of the most relevant and widely used methods employed in this field, providing detailed protocols that molecular and cellular biologists could easily adopt in their research programs on RTKs.

Keywords

Aberrant expression Negative regulation Pharmacological targets Protein expression RTK activation RTK signaling Single-pass membrane proteins Trafficking

Editors and affiliations

  • Serena Germano
    • 1
  1. 1.Necker HospitalParisFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-1789-1
  • Copyright Information Springer Science+Business Media New York 2015
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-1788-4
  • Online ISBN 978-1-4939-1789-1
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • About this book