Notch Signaling

Methods and Protocols

  • Hugo J. Bellen
  • Shinya Yamamoto

Part of the Methods in Molecular Biology book series (MIMB, volume 1187)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Shinya Yamamoto, Karen L. Schulze, Hugo J. Bellen
    Pages 1-14
  3. Patricia Chastagner, Christel Brou
    Pages 87-100
  4. Benjamin E. Housden, Jinghua Li, Sarah J. Bray
    Pages 101-113
  5. Swananda Marathe, Lavinia Alberi
    Pages 115-129
  6. Jinghua Li, Benjamin E. Housden, Sarah J. Bray
    Pages 131-141
  7. Hiromi Shimojo, Yukiko Harima, Ryoichiro Kageyama
    Pages 169-179
  8. K. G. Guruharsha, Kazuya Hori, Robert A. Obar, Spyros Artavanis-Tsakonas
    Pages 181-192
  9. Pat Whiteman, Christina Redfield, Penny A. Handford
    Pages 193-208
  10. Lutgarde Serneels, Ina Tesseur, Bart De Strooper
    Pages 223-229
  11. Will Bailis, Yumi Yashiro-Ohtani, Warren S. Pear
    Pages 247-254
  12. Robert Liefke, Tilman Borggrefe
    Pages 255-276
  13. Aiguo Xu, Kenneth D. Irvine
    Pages 277-284
  14. Pau Formosa-Jordan, David Sprinzak
    Pages 285-310
  15. Gerdien E. De Kloe, Bart De Strooper
    Pages 311-322
  16. Jun-ichiro Koga, Masanori Aikawa
    Pages 335-342
  17. Back Matter
    Pages 343-351

About this book


Notch Signaling: Methods and Protocols focuses on molecular, biochemical, and bioinformatics aspects of Notch signaling. Chapters analyze the Notch interactome, post-translational modifications of Notch, ligand binding assays, methods to assess proteolytic cleavage, and transcriptional targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Notch Signaling: Methods and Protocols is a valuable contribution to hundreds of labs and thousands of scientists who pursue this research area with vigor.


Notch activity in cells Notch interactome Notch signaling genetic methods image Notch signaling post-translational modifications of Notch proteolytic cleavage transcriptional targets visualize oscillation

Editors and affiliations

  • Hugo J. Bellen
    • 1
  • Shinya Yamamoto
    • 2
  1. 1.Dept.of Molecular and Human Genetics, Program in Developmental Biology, Dept. of Neuroscience, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Howard Hughes Medical InstituteBaylor College of MedicineHoustonUSA
  2. 2.Dept. of Molecular and Human Genetics, Program in Developmental Biology, Jan and Dan Duncan Neurological Research Institute at Texas Children's HospitalBaylor College of MedicineHoustonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2014
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-1138-7
  • Online ISBN 978-1-4939-1139-4
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site