Mechanisms of Physical and Emotional Stress

  • George P. Chrousos
  • D. Lynn Loriaux
  • Philip W. Gold

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 245)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. George P. Chrousos, D. Lynn Loriaux, Philip W. Gold
      Pages 3-7
  3. Basic Mechanisms of the Stress Response

    1. Front Matter
      Pages 9-9
    2. I. J. Kopin, G. Eisenhofer, D. Goldstein
      Pages 11-23
    3. George F. Koob, Karen Thatcher-Briton, Abdelouahhab Tazi, Michel Le Moal
      Pages 25-34
    4. Bruce S. McEwen, Roberta E. Brinton, Robert M. Sapolsky
      Pages 35-45
    5. Greti Aguilera, Abdul-Badi Abou Samra, James P. Harwood, Kevin J. Catt
      Pages 83-105
    6. Errol B. De Souza, George Battaglia
      Pages 123-136
    7. V. Guillaume, M. Grino, G. Peyre, B. Conte-Devolx, C. Oliver
      Pages 137-141
    8. Celia D. Sladek, John A. Olschowka
      Pages 157-165
    9. Aldo E. Calogero, Renato Bernardini, Philip W. Gold, George P. Chrousos
      Pages 167-181
  4. Stress and Immunity

    1. Front Matter
      Pages 201-201
    2. Henry N. Claman
      Pages 203-208
    3. Bernard Rothhut, Françoise Russo-Marie
      Pages 209-215

About this book

Introduction

It has been over 50 years since Hans Selye formulated his concept of stress. This came after the isolation of epinephrine and norepinephrine and after the sympathetic system was associated with Walter Cannon's "fight or flight" response. The intervening years have witnessed a number of dis­ coveries that have furthered our understanding of the mechanisms of the stress response. The isolation, identification and manufacture of gluco­ corticoids, the identification and synthesis of ACTH and vasopressin, and the demonstration of hypothalamic regulation of ACTH secretion were pivotal discoveries. The recent identification and synthesis of CRR by Willie Vale and his colleagues gave new impetus to stress research. Several new concepts of stress have developed as a result of advances in bench research. These include the concept of an integrated "stress sys­ tem", the realization that there are bi-directional effects between stress and the immune system, the suggestion that a number of common psychiatric disorders represent dysregulation of systems responding to stress, and the epidemiologic association of stress with the major scourges of humanity.

Keywords

CNS behavior biology pharmacology regulation reproduction

Editors and affiliations

  • George P. Chrousos
    • 1
  • D. Lynn Loriaux
    • 1
  • Philip W. Gold
    • 1
  1. 1.National Institute of HealthBethesdaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4899-2064-5
  • Copyright Information Springer-Verlag US 1988
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4899-2066-9
  • Online ISBN 978-1-4899-2064-5
  • Series Print ISSN 0065-2598
  • About this book