The Biology of Tumors

1. T-Cell and NK-Mediated Surveillance of Cancer

   • M. J. W. Visseren, S. H. van der Burg, M. Vierboom, M. E. Ressing, R. Toes, R. Offringa et al.

   Pages 249-271

2. Regulation of Leukocyte-Endothelial Cell Interactions in Tumor Immunity

   • Sharon S. Evans, Margaret Frey, David M. Schleider, Robert A. Bruce, Wan-chao Wang, Elizabeth A. Repasky et al.

   Pages 273-286

3. Role of Endothelial versus Smooth Muscle Cells in Blood Vessel Formation

   • Peter Carmeliet, Désiré Collen

   Pages 287-303

4. The Role of Vascular Endothelial Growth Factor in Tumor Angiogenesis

   • Georg Breier, Annette Damert, Sabine Blum, Ernst Reichmann, Karl H. Plate, Werner Risau

   Pages 305-318

5. Tumor Microcirculation

   • Rakesh K. Jain

   Pages 319-345

6. Back Matter

   Pages 347-351

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The Ninth Annual Pezcoller Symposium entitled "The Biology of Tumors" was held in Rovereto, Italy, June 4-7, 1997. It focused on the genetic mechanisms underlying het­ erogeneity of tumor cell populations and tumor cell differentiation, on interactions be­ tween tumor cells and cells of host defenses, and the mechanisms of angiogenesis. With presentations at the cutting edge of progress and stimulating discussions, this symposium addressed issues related to phenomena concerned with cell regulation and cell interactions as determined by activated genes through the appropriate and timely media­ tion of gene products. Important methodologies that would allow scientists to measure dif­ ferentially genes and gene products and thus validate many of the mechanisms of control currently proposed were considered, as were the molecular basis of tumor recognition by the immune system, interactions between cells and molecular mechanisms of cell regula­ tion as they are affected by or implemented through these interactions. The molecular and cellular mechanisms of tumor vascularization were also discussed. It was recognized that angiogenesis provides a potential site of therapeutic intervention and this makes it even more important to understand the mechanisms underlying it. We wish to thank the participants in the symposium for their substantial contribu­ tions and their participation in the spirited discussions that followed. We would also like to thank Drs.

• DNA
• Microarray
• biology
• gene expression
• genes
• signal transduction
• transcription

• Roswell Park Cancer Institute, Buffalo, USA

  Enrico Mihich

• Kimmel Cancer Institute, Philadelphia, USA

  Carlo Croce

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