Chemical Aspects of Enzyme Biotechnology

1. Vitamin B12

   1. Vitamin B12: The Biosynthesis of the Tetrapyrrole Ring: Mechanism and Molecular Biology

      • Peter M. Jordan

      Pages 245-264

   2. Biosynthesis of Vitamin B12: Biosynthetic and Synthetic Researches

      • Alan R. Battersby

      Pages 265-280

   3. On the Methylation Process and Cobalt Insertion in Cobyrinic Acid Biosynthesis

      • G. Müller, K. Hlineny, E. Savvidis, F. Zipfel, J. Schmiedl, E. Schneider

      Pages 281-298

   4. Biochemical and Genetic Studies on Vitamin B₁₂ Synthesis in Pseudomonas dentrificans

      • J. Crouzet, F. Blanche, B. Cameron, D. Thibaut, L. Debussche

      Pages 299-315

   5. Genetic Approaches to the Synthesis and Physiological Significance of B12 in Salmonella typhimurium

      • John R. Roth, Charlotte Grabau, Thomas G. Doak

      Pages 317-332

   6. Mechanistic and Evolutionary Aspects of Vitamin B12 Biosynthesis

      • A. Ian Scott

      Pages 333-354

2. Back Matter

   Pages 355-359

   PDF

The Industry-University Cooperative Chemistry Program has sponsored seven previous international symposia covering a wide variety of topics of interest to industrial and academic chemists. The eighth IUCCP symposium, held March 19-22, 1990, at Texas A&M University, represents a deviation from the former symposia, in that it is the first of a two-symposium series dedicated to the rapidly moving new field of industrial biochemistry that has beco~e known as biotechnology. Biotechnology is really not a new discipline, but rather is a term coined to describe the new and exciting commercial applications of biochemistry. The development of the field of biotechnology is a direct result of recombinant DNA technology, which began in earnest about 15 years ago. Today, we can routinely do experiments that were inconceivable in the early 1970's. Only comparatively simple technology available even in small laboratories is required to synthesize a gene and from it, to produce vast amounts of biological materials of enormous commercial value. These technical developments and others have stimulated increased activities in the field of enzyme biotechnology, using enzymes to catalyze "unnatural" reactions to produce complex molecules with stereochemical precision. It is true today, we can readily produce DNA fragments that will encode any amino acid sequence that we might desire, but at this point, our foundation of basic knowledge falls short. The dream of "designer enzymes" is still a fantasy, but the current wave of research activity and exciting new developments suggest that in the future the dream may become a reality.

• Amino acid
• Coenzym
• DNA
• Glutamin
• biochemistry
• enzymes

• Texas A&M University, College Station, USA

  Thomas O. Baldwin, Frank M. Raushel, A. Ian Scott

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