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Alterations of Metabolites in the Nervous System

  • Abel Lajtha

Table of contents

  1. Front Matter
    Pages i-xxvii
  2. Peter S. Spencer, Matthew S. Miller, Stephen M. Ross, Bradley W. Schwab, Mohammad I. Sabri
    Pages 31-65
  3. W. Graham McLean, Martin Frizell, Johan Sjöstrand
    Pages 67-86
  4. Michael J. Zigmond, Edward M. Stricker
    Pages 87-102
  5. Paul J. Goodnick, Samuel Gershon
    Pages 103-149
  6. Stephen Zamenhof
    Pages 151-172
  7. Albert Y. Sun, Grace Y. Sun, Laurie L. Foudin
    Pages 173-202
  8. Sidney Roberts
    Pages 203-218
  9. Sujata Tewari, Igor A. Sytinsky
    Pages 219-261
  10. Henry Sershen
    Pages 263-278
  11. Doris H. Clouet
    Pages 279-297
  12. Joseph T. Coyle
    Pages 299-329
  13. J. E. Leysen, C. J. E. Niemegeers
    Pages 331-361
  14. Robert J. DeLorenzo, Larry H. Dashefsky
    Pages 363-403
  15. Sze-Chuh Cheng
    Pages 405-430
  16. John R. Smythies
    Pages 431-442
  17. Arnulf H. Koeppen
    Pages 443-506
  18. Marian W. Kies
    Pages 533-552
  19. Edwin M. Nemoto
    Pages 553-588
  20. Back Matter
    Pages 589-595

About this book

Introduction

In neurosciences one may say, '"All roads lead to Rome. " It seems as though wherever one starts, the course of investigation leads to the same major ques­ tions about nervous system function and dysfunction. In thinking about what to write in this preface, it occurred to me that it might be best to deal with that with which I am most familiar and to trace to some extent my own '"road to Rome. '' As I look over my work of the last 37 years, it becomes clear to me that it can be epitomized as a search for patterns. What usually began as a single­ minded devotion to in-depth analysis of one or a small number of variables always has led to questions of how the results might relate to the whole living unit, whether it is cell, tissue, or organism. For a number of years after my discovery in the vertebrate central nervous system of -y-aminobutyric acid (GABA) and the enzyme which forms it, L­ glutamate decarboxylase (GAD), and the identification of GABA as a major inhibitory neurotransmitter by others, I felt that my laboratory, largely bio­ chemical, was wandering in the wilderness of the complexities of the vertebrate CNS without definitively coming to terms with problems related to GABAergic transmitter functions and the roles of GABA neurons in information processing.

Keywords

Nervous System information processing neurochemistry neurons neuroscience

Editors and affiliations

  • Abel Lajtha
    • 1
  1. 1.Center for NeurochemistryWards IslandUSA

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