Membrane Dynamics and Domains

Subcellular Biochemistry

  • Peter J. Quinn

Part of the Subcellular Biochemistry book series (SCBI, volume 37)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Membrane Domain Structure

    1. Front Matter
      Pages 1-1
    2. Janet M. Oliver, Janet R. Pfeiffer, Zurab Surviladze, Stanly L. Steinberg, Karin Leiderman, Margaret L. Sanders et al.
      Pages 3-34
  3. Membrane Domain Composition

    1. Front Matter
      Pages 119-119
    2. Bernd Wollscheid, Priska D. von Haller, Eugene Yi, Samuel Donohoe, Kelly Vaughn, Andrew Keller et al.
      Pages 121-152
    3. Kamen S. Koumanov, Claude Wolf, Peter J. Quinn
      Pages 153-163
  4. Creation of Membrane Microdomains

  5. Regulation of Domain Formation

    1. Front Matter
      Pages 283-283
    2. Frances J. Sharom, Galina Radeva
      Pages 285-315
    3. Claude Wolf, Peter J. Quinn
      Pages 317-357
    4. Ruud Veldhuizen, Fred Possmayer
      Pages 359-388
  6. Signal Transduction Processes

    1. Front Matter
      Pages 389-389
    2. Michael Schrader
      Pages 391-421
  7. Domain Dynamics in Disease

    1. Front Matter
      Pages 423-423
    2. Marie-Odile Parat, Paul L. Fox
      Pages 425-441

About this book

Introduction

The fluid-mosaic model of membrane structure formulated by Singer and Nicolson in the early 1970s has proven to be a durable concept in terms of the principles governing the organization of the constituent lipids and proteins. During the past 30 or so years a great deal of information has accumulated on the composition of various cell membranes and how this is related to the dif­ ferent functions that membranes perform. Nevertheless, the task of explaining particular functions at the molecular level has been hampered by lack of struc­ tural detail at the atomic level. The reason for this is primarily the difficulty of crystallizing membrane proteins which require strategies that differ from those used to crystallize soluble proteins. The unique exception is bacteriorhodopsin of the purple membrane of Halobacterium halobium which is interpolated into a membrane that is neither fluid nor in a mosaic configuration. To date only 50 or so membrane proteins have been characterised to atomic resolution by diffraction methods, in contrast to the vast data accumulated on soluble proteins. Another factor that has been difficult to explain is the reason why the lipid compliment of membranes is often extremely complex. Many hundreds of different molecular species of lipid can be identified in some membranes. Remarkably, the particular composition of each membrane appears to be main­ tained within relatively narrow limits and its identity distinguished from other morphologically-distinct membranes.

Keywords

Lipid biochemistry cell biology metabolism regulation

Editors and affiliations

  • Peter J. Quinn
    • 1
  1. 1.Department of Life SciencesKing’s College LondonLondonUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4757-5806-1
  • Copyright Information Springer-Verlag US 2004
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4419-3447-5
  • Online ISBN 978-1-4757-5806-1
  • Series Print ISSN 0306-0225
  • About this book