Flavonoids in Cell Function

1. Front Matter

   Pages i-viii

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2. Flavonoids in Cell Function

   • John A. Manthey, Béla S. Buslig, Michael E. Baker

   Pages 1-7

3. Host Recognition by Pathogenic Fungi Through Plant Flavonoids

   • David Straney, Rana Khan, Reynold Tan, Savita Bagga

   Pages 9-22

4. Signalling in Arbuscular Mycorrhiza: Facts and Hypotheses

   • Horst Vierheilig, Yves Piché

   Pages 23-39

5. The Use of a Photoactivatable Kaempferol Analogue to Probe the Role of Flavonol 3-O-Galactosyltransferase in Pollen Germination

   • Loverine P. Taylor, Keith D. Miller

   Pages 41-50

6. Flavonoids: Signal Molecules in Plant Development

   • Ho-Hyung Woo, Gary Kuleck, Ann M. Hirsch, Martha C. Hawes

   Pages 51-60

7. Modern Analytical Techniques for Flavonoid Determination

   • Mark A. Berhow

   Pages 61-76

8. HPLC-Mass Spectrometry of Isoflavonoids in Soy and the American Groundnut, Apios Americana

   • S. Barnes, C-C. Wang, M. Kirk, M. Smith-Johnson, L. Coward, N. C. Barnes et al.

   Pages 77-88

9. History as a Tool in Identifying “New” Old Drugs

   • John M. Riddle

   Pages 89-94

10. Potential Health Benefits from the Flavonoids in Grape Products on Vascular Disease

    • John D. Folts

    Pages 95-111

11. Polyphenol Antioxidants in Citrus Juices: in vitro and in vivo Studies Relevant to Heart Disease

    • Joe A. Vinson, Xiquan Liang, John Proch, Barbara A. Hontz, John Dancel, Nicole Sandone

    Pages 113-122

12. Inhibition of Colonic Aberrant Crypt Formation by the Dietary Flavonoids (+)-Catechin and Hesperidin

    • Adrian A. Franke, Laurie J. Custer, Robert V. Cooney, Yuichiro Tanaka, Meirong Xu, Roderick H. Dashwood

    Pages 123-133

13. The Citrus Methoxyflavone Tangeretin Affects Human Cell-Cell Interactions

    • Marc E. Bracke, Tom Boterberg, Herman T. Depypere, Christophe Stove, Georges Leclercq, Marc M. Mareel

    Pages 135-139

14. Xanthine Oxidase and Xanthine Dehydrogenase Inhibition by the Procyanidin-Rich French Maritime Pine Bark Extract, Pycnogenol®: A Protein Binding Effect

    • Hadi Moini, Qiong Guo, Lester Packer

    Pages 141-149

15. Human 17β-Hydroxysteroid Dehydrogenase Type 5 is Inhibited by Dietary Flavonoids

    • A. Krazeisen, R. Breitling, G. Möller, J. Adamski

    Pages 151-161

16. Interactions of Flavones and Other Phytochemicals with Adenosine Receptors

    • Kenneth A. Jacobson, Stefano Moro, John A. Manthey, Patrick L. West, Xiao-duo Ji

    Pages 163-171

17. Regulation of Lipoprotein Metabolism in HepG2 Cells by Citrus Flavonoids

    • Elzbieta M. Kurowska, John A. Manthey

    Pages 173-179

18. Anti-Inflammatory Actions of a Micronized, Purified Flavonoid Fraction in Ischemia/Reperfusion

    • Ronald J. Korthuis, Dean C. Gute

    Pages 181-190

19. Flavonoids and Gene Expression in Mammalian Cells

    • Shiu-Ming Kuo

    Pages 191-200

20. Back Matter

    Pages 201-209

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The discovery of biological activity associated with flavonoid contaminants in vitamin C preparations from bell peppers and lemons by Szent-Gyorgyi and his associates opened a floodgate of research into the biological functions of this ubiquitous and diverse group of compounds. Since then, a broad range of physiological and biochemical activities were discovered in living systems including most plants and animals. With the continued discovery, isolation and identification of new natural and synthetic compounds exhibiting biological activities, entire research programs are devoted to wide ranging investigations to nearly every conceivable area, from microbial and plant interaction, growth regulation and development to physiological, genetical, medicinal actions and uses in animals. This volume is based on presentations made at a Symposium, titled Flavonoids in Cell Function, held during the 219'h National Meeting of the American Chemical Society held in San Francisco, California on March 29-30, 2000. The book is not intended to be a comprehensive treatise on flavonoid research, only a sampling of recent results. The papers cover a range of topics discussing various approaches to flavonoid study, starting at plant­ microbe communication through analytical methods to medicinal and systemic implications of these compounds in animal cells and systems. The organizers would like to express their thanks to Cargill Foods, Inc., Minneapolis, Minnesota and the Division of Agricultural and Food Chemistry of the American Chemical Society for financial support. A great deal of thanks is also due to the authors without whose cooperation and patience this volume would not be realized.

• catechin
• gene expression
• metabolism
• plant development
• soy

• USDA Citrus and Subtropical Products Laboratory, Winter Haven, USA

  Béla S. Buslig, John A. Manthey