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Biomedical Aspects of Drug Targeting

  • Vladimir Muzykantov
  • Vladimir Torchilin

Table of contents

  1. Front Matter
    Pages i-xvii
  2. General Principles of Drug Targeting

    1. Front Matter
      Pages 1-1
    2. Vladimir P. Torchilin
      Pages 3-26
    3. Vladimir R. Muzykantov
      Pages 27-44
  3. Cardiovascular Targeting

    1. Front Matter
      Pages 45-45
    2. Ban-An Khaw
      Pages 47-67
    3. Ban-An Khaw
      Pages 69-83
    4. Karlheinz Peter, Christoph Bode
      Pages 85-106
    5. Vladimir R. Muzykantov
      Pages 129-148
    6. Jonathan R. Lindner, Alexander L. Klibanov, Klaus Ley
      Pages 149-172
    7. Paul N. Reynolds, Sergei M. Danilov
      Pages 173-190
  4. Tumor Targeting

    1. Front Matter
      Pages 191-191
    2. Ruth Duncan
      Pages 193-209
    3. Sophia Ran, Michael Rosenblum, Philip E. Thorpe
      Pages 229-248
    4. Alan L. Epstein, Leslie A. Khawli, Peisheng Hu
      Pages 249-274
    5. Susanna M. Rybak, Michaela Arndt, Juergen Krauss, Dianne L. Newton, Bang K. Vu, Zhongyu Zhu
      Pages 275-290
    6. Victor S. Goldmacher, Walter A. Blättler, John M. Lambert, Ravi V. J. Chari
      Pages 291-309
  5. Targeting to the Brain

    1. Front Matter
      Pages 311-311
    2. Ken-ichi Hosoya, Sumio Ohtsuki, Tetsuya Terasaki
      Pages 313-326
    3. Ranajoy Sarkar, David S. Halpern, Steven K. Jacobs, D. Robert Lu
      Pages 327-345
    4. Margaret A. Petty, Eng H. Lo
      Pages 347-357
  6. Miscellaneous, New Horizons in Targeting

    1. Front Matter
      Pages 379-379
    2. John W. Babich
      Pages 381-401
    3. Seth H. Pincus, Hua Fang, Royce Wilkinson
      Pages 403-417
    4. John Woodley
      Pages 419-439
    5. Sabine Boeckle, Ernst Wagner, Manfred Ogris
      Pages 441-458
    6. Dennis E. Discher, Peter Photos, Fariyal Ahmed, Ranganath Parthasrathy, Frank S. Bates
      Pages 459-471
    7. Volkmar Weissig, Gerard D’ Souza, Vladimir P. Torchilin
      Pages 473-495
  7. Back Matter
    Pages 497-506

About this book

Introduction

Drugs usually have no natural affinity for the cells, tissues and organs where therapeutic effects are needed, which frequently results in low efficiency and unwanted side effects. This concern is even more profound when using highly potent and cytotoxic anticancer drugs or specific agents, such as enzymes and genetic materials, since their effective and safe action requires precise cellular or even sub-cellular addressing in the target organ. To meet safety, efficiency and specificity requirements, drugs somehow must be targeted to the sites of their expected therapeutic action. The idea of the "magic bullet," or drug targeting, proposed by Erlich a century ago, generates great and continuously growing interest in biomedical, industrial and financial circles. This book is focused on the strategies designed to target therapeutic or diagnostic agents to the disease sites. In an attempt to include in this volume the set of chapters reflecting both traditional and emerging areas of drug targeting, we have contacted many leading scientists in the field asking for their contributions. Their responses were most favorable and encouraging. As a result, we have succeeded in assembling a series of outstanding contributions reflecting practically all the key areas of drug targeting. The final structure of this book is as follows.

Keywords

Epoxidharze Retention Tumor apoptosis endothelium imaging polymer tissue

Editors and affiliations

  • Vladimir Muzykantov
    • 1
  • Vladimir Torchilin
    • 2
  1. 1.School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.School of PharmacyNortheastern UniversityBostonUSA

Bibliographic information