Genetic Immunization

  • Constantin A. Bona
  • Adrian I. Bot

Table of contents

  1. Front Matter
    Pages i-xi
  2. Constantin A. Bona, Adrian I. Bot
    Pages 1-10
  3. Constantin A. Bona, Adrian I. Bot
    Pages 11-23
  4. Constantin A. Bona, Adrian I. Bot
    Pages 25-33
  5. Constantin A. Bona, Adrian I. Bot
    Pages 99-108
  6. Constantin A. Bona, Adrian I. Bot
    Pages 109-120
  7. Constantin A. Bona, Adrian I. Bot
    Pages 121-141
  8. Back Matter
    Pages 143-179

About this book


Wolf's discovery demonstrating that a reporter gene is expressed in myocytes subsequent to injection of naked DNA, was exploited by immunologists and vaccinologists to develop a new generation of vaccines. This observation galvanized the research and in a short lapse of time, an oceanic volume of knowledge has been accumulated. The research carried out in a variety of animal models showed the efficacy of genetic immunization against viruses, bacteria, and some parasites by the ability to induce a strong priming effect resulting from long-lasting persistence of plasmid as episomes. Furthermore, it was demonstrated that newborn or infant immune unresponsiveness to classical vaccines can be corrected by genetic immunization. The applications of genetic immunization for prophylaxis of infections was extended to immunotherapy, namely, cancerous, auto­ immune, and allergic diseases. Immunologists have provided pertinent information on the cellular basis of the immune responses elicited by genetic immunization, and molecular biologists have established the molecular basis of intrinsic adjuvant properties of plasmids.


Antigen DNA allergy autoimmune disease autoimmunity bacteria diseases immunology parasite vaccination vaccine virus

Authors and affiliations

  • Constantin A. Bona
    • 1
  • Adrian I. Bot
    • 2
  1. 1.Mount Sinai School of MedicineNew YorkUSA
  2. 2.Alliance Pharmaceutical Corp.San DiegoUSA

Bibliographic information