Circular Dichroism and the Conformational Analysis of Biomolecules

1. Front Matter

   Pages i-x

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2. Remembrance of Things Past

   • Jen Tsi Yang

   Pages 1-24

3. Theory of Circular Dichroism of Proteins

   • Robert W. Woody

   Pages 25-67

4. Determination of Protein Secondary Structure

   • Sergei Yu. Venyaminov, Jen Tsi Yang

   Pages 69-107

5. Aromatic and Cystine Side-Chain Circular Dichroism in Proteins

   • Robert W. Woody, A. Keith Dunker

   Pages 109-157

6. Stopped-Flow Circular Dichroism

   • Kunihiro Kuwajima

   Pages 159-182

7. Circular Dichroism of Collagen and Related Polypeptides

   • Rajendra S. Bhatnagar, Craig A. Gough

   Pages 183-199

8. CD Spectroscopy and the Helix-Coil Transition in Peptides and Polypeptides

   • Neville R. Kallenbach, Pingchiang Lyu, Hongxing Zhou

   Pages 201-259

9. The β Sheet ⇌ Coil Transition of Polypeptides, as Determined by Circular Dichroism

   • Luanne Tilstra, Wayne L. Mattice

   Pages 261-283

10. Turns

    • András Perczel, Miklós Hollósi

    Pages 285-380

11. Differentiation between Transmembrane Helices and Peripheral Helices by the Deconvolution of Circular Dichroism Spectra of Membrane Proteins

    • Gerald D. Fasman

    Pages 381-412

12. Theories of Circular Dichroism for Nucleic Acids

    • David Keller

    Pages 413-431

13. Determination of the Conformation of Nucleic Acids by Electronic CD

    • W. Curtis Johnson Jr.

    Pages 433-468

14. Circular Dichroism of Protein-Nucleic Acid Interactions

    • Donald M. Gray

    Pages 469-500

15. Carbohydrates

    • Eugene S. Stevens

    Pages 501-530

16. Chaperones

    • Gerald D. Fasman

    Pages 531-554

17. Vibrational Circular Dichroism

    • Timothy A. Keiderling

    Pages 555-598

18. Circular Dichroism Using Synchrotron Radiation

    • John C. Sutherland

    Pages 599-633

19. Circular Dichroism Instrumentation

    • W. Curtis Johnson Jr.

    Pages 635-652

20. Vibrational Raman Optical Activity of Biomolecules

    • Laurence D. Barron, Lutz Hecht, Alasdair F. Bell

    Pages 653-695

''Excellent and very timely....It will undoubtedly become a standard reference for the application of circular dichroism (CD) to biomolecules.'' --- Quarterly Review of Biology, March 1997 ''[T]estament to the book's utility is the fact that during the course of my review I had to 'rescue' it from the desks of graduate students on an almost daily basis. In summary, this is a great book.'' --- American Scientist ''Well documented chapters provide a very good insight into the problems surrounding the conformation of biomacromolecules...An indispensible source of information.'' --- Nahrung, 42(2), 1998 Renowned experts present the first state-of-the-art description of circular dichroism spectroscopy (CD). Chapters present in-depth discussions of the history of the field, the theory of CD for application to globular proteins, membrane proteins, peptides, nucleic acids and their interactions, carbohydrates, and instrumentation. Discussions also feature new techniques using synchrotron radiation, vibrational Raman optical activity, and vibrational CD. More than 250 illustrations supplement the text.

• Peptide
• Polypeptide
• Secondary structure
• protein
• proteins
• spectroscopy

• Department of Biochemistry, Brandeis University, Waltham, USA

  Gerald D. Fasman