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Purine Metabolism in Man

Biochemistry and Pharmacology of Uric Acid Metabolism

  • Book
  • © 1974


Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 41)

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About this book

Gout and urie acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of urie acid excretion, although still posing difficult problems, appears to approach clari­ fication.

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Table of contents (62 chapters)

  1. Gout

    1. Etiology of Purine Overproduction in Gout

    2. Effects of Diet, Weight, and Stress on Purine Metabolism

    3. Relationship Between Carbohydrate, Lipid, and Purine Metabolism

Editors and Affiliations

  • Division of Metabolic Disease, Rogoff-Wellcome Medical Research Institute, Beilinson Hospital, Petah-Tikva, Israel

    Oded Sperling, Andre Vries

  • Department of Medicine, Duke University Medical Center, Durham, USA

    James B. Wyngaarden

Bibliographic Information

  • Book Title: Purine Metabolism in Man

  • Book Subtitle: Biochemistry and Pharmacology of Uric Acid Metabolism

  • Editors: Oded Sperling, Andre Vries, James B. Wyngaarden

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI:

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1974

  • Softcover ISBN: 978-1-4757-1435-7Published: 15 April 2013

  • eBook ISBN: 978-1-4757-1433-3Published: 11 November 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XXV, 476

  • Topics: Biochemistry, general

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