A Multidisciplinary Approach to Myelin Diseases

1. Immunological Aspects of Myelin Diseases

   1. The Role of Antibodies Against Myelin Surface Antigens in Demyelination in Chronic EAE

      • H. Lassmann, C. Linington

      Pages 219-225

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   2. Risk Factors in Multiple Sclerosis-Implications for Pathogenesis

      • William A. Sibley

      Pages 227-232

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   3. Autoaggressive T Lymphocyte in Autoimmune Diseases of the Central Nervous System: Interaction of Autoimmune T Cells with Astroglia

      • H. Wekerle, D. Sun, R. Meyermann

      Pages 233-242

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   4. Suppression of Demyelinating Diseases by Synthetic Copolymers

      • R. Arnon, D. Teitelbaum

      Pages 243-250

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   5. Immunosuppression in Experimental Allergic Encephalomyelitis

      • L. Massacesi, A. L. Abbamondi, E. Castigli, L. Amaducci

      Pages 251-258

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   6. Humoral Immunity in Multiple Sclerosis Cerebrospinal Fluid: Role of the Blood-Brain Barrier Integrity in the Detection of Intrathecally Synthesized Immunoglobulins

      • P. Gallo, S. Morara, M. Piccinno, F. Bracco, B. Tavolato

      Pages 259-265

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   7. Cerbrospinal Fluid Markers in Multiple Sclerosis

      • A. R. Massaro, G. Carbone

      Pages 267-274

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2. Demyelinating Diseases

   1. Front Matter

      Pages 275-275

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   2. Nervous System Origin of Renal Galactosylceramide in the Twitcher Mouse Mutant

      • M. Katayama, D. S. Siegel, K. Suzuki

      Pages 277-283

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   3. Virus Induced Slow Infections of the Central Nervous System

      • C. J. Gibbs Jr.

      Pages 285-302

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   4. Pathogenesis of Visna

      • G. Georgsson, P. A. Palsson, G. Petursson

      Pages 303-318

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   5. Neurochemical Changes in White Matter of Patients with Alzheimer’s Disease

      • L. Svennerholm, C-G. Gottfries, I. Karlsson

      Pages 319-328

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   6. Central Nervous System Demyelination in Herpes Simplex Virus Type 2 Infection

      • J. R. Martin, S. Suzuki, H. deF Webster

      Pages 329-340

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3. Remyelination and Myelin Repair

   1. Front Matter

      Pages 341-341

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   2. Myelination Capacity of Transplanted Oligodendrocytes

      • M. Gumpel, F. Lachapelle, C. Lubetzki, A. Gansmüller, A. Baron-Van Evercooren, P. Lombrail et al.

      Pages 343-352

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   3. Proliferation of Oligodendrocytes and Remyelination

      • S. K. Ludwin

      Pages 353-361

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   4. The Effects of Hypoxia on Oligodendrocytes in Primary Mouse CNS Cell Cultures

      • N. Herschkowitz, R. Reynolds, E. Bossi

      Pages 363-370

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4. Clinical Aspects of New Discoveries

   1. Front Matter

      Pages 371-371

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   2. Clinical Aspects of New Discoveries

      • G. Serlupi Crescenzi

      Pages 373-400

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5. Back Matter

   Pages 401-406

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The present book is based on the papers presented during an inter­ disciplinary meeting which was held in Rome October 27-30, 1986, at the Istituto Superiore di Sanita under the sponsorship of NATO, and with a financial contribution of the Cassa di Risparmio di Roma. The meeting was of great interest because, for the first time, a group of highly qualified scientists specializing in different fields were gathered together to discuss the problem of demyelinating diseases. In thi. context molecular biologists, immunologists, virologists, and lipid chemists could discuss with clinicians for four days every aspect of demyelinating diseases. They shared results of the more recent research with the hope that more knowledge of the myelinating process will eventually succeed in finding new treatments for these diseases. The meeting was successful, perhaps in part because discussions during lunches and dinners provided an opportunity for the exchange of new ideas. This was apparent in the discussions held after the presen­ tation of each paper and was summarized in the very lively round table which was held on the last day. The editor wishes to express his thanks to the scientific committee members: N. Baumann, C. Fieschi, G. Macchi, J.M. Matthieu, K. Suzuki. It was their advice that made the choice of participants and subjects so successful. The organizer also acknowledge the organizing support of NATO in preparing these proceedings. Acknowledgments have to be offered to Dr. S. Salvati, Dr. A.M.

• Alzheimer's disease
• Alzheimer´s disease
• brain
• diseases
• immunology
• multiple sclerosis
• myelin
• nervous system
• research
• treatment

• Istituto Superiore di Sanità, Rome, Italy

  G. Serlupi Crescenzi

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