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The Adenoviruses

  • Hardold S. Ginsberg

Part of the The Viruses book series (VIRS)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Harold S. Ginsberg
    Pages 1-4
  3. M. V. Nermut
    Pages 5-34
  4. John S. Sussenbach
    Pages 35-124
  5. C. S. H. Young, T. Shenk, Harold S. Ginsberg
    Pages 125-172
  6. Phillip A. Sharp
    Pages 173-204
  7. Thomas J. Kelly Jr.
    Pages 271-308
  8. Lennart Philipson
    Pages 309-337
  9. Daniel F. Klessig
    Pages 399-449
  10. Stephen E. Straus
    Pages 451-496
  11. Masahide Ishibashi, Hiroshi Yasue
    Pages 497-562
  12. Kenneth I. Berns
    Pages 563-592
  13. Back Matter
    Pages 593-605

About this book

Introduction

The discovery of adenoviruses naturally induced a new interest in viruses of the human upper respiratory tract since previously unknown viruses infecting this portion of the human body had not been identified in 20 years, and their unique characteristics stimulated investigations into the biochemical events essential for replication of animal viruses. Indeed, the field of molecular virology has evolved during the period since their dis­ covery, and adenoviruses have played a major role in this development. The exciting discoveries made with adenoviruses have had such a pro­ found effect on knowledge in basic virology, molecular biology, viral ge­ netics, human and animal infections, and cell transformation that this seemed a propitious time to have some of the major contributors review this field. This volume pays tribute to the late Wallace Rowe, Robert Huebner, and Maurice Hilleman whose initial discoveries of adenoviruses have tremendously enriched virology. Harold S. Ginsberg vii Contents Chapter 1 An Overview 1 Harold S. Ginsberg Chapter 2 The Architecture of Adenoviruses M. V. Nermut I. Introduction ................................... . 5 II. Chemical and Physical Properties ................... . 6 III. Virus Capsid: Composition and Organization .......... . 7 A. Hexon ..................................... . 10 B. Penton .................................... . 12 C. Other Virus Polypeptides Associated with the Capsid 13 D. Organization of the Capsid ..................... . 14 IV. Virus Core .................................... . 15 A. Evidence for the Core Shell ..................... . 17 B. Organization of the DNA-Protein Complex (Nucleoc- sid) ....................................... . 18 C. Tentative Model of the Adenovirus Nucleocapsid ... . 22 V. Model of the Adenovirion ......................... . 29 32 References .......................................... .

Keywords

Polypeptide development infection infections protein virus

Editors and affiliations

  • Hardold S. Ginsberg
    • 1
  1. 1.College of Physicians and Surgeons of Columbia UniversityNew YorkUSA

Bibliographic information