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Physical and Chemical Mechanisms in Molecular Radiation Biology

  • William A. Glass
  • Matesh N. Varma

Part of the Basic Life Sciences book series (BLSC, volume 58)

Table of contents

  1. Front Matter
    Pages i-x
  2. Introduction to the Problem

    1. Front Matter
      Pages 1-1
    2. Eric J. Hall, Greg A. Freyer
      Pages 3-25
  3. Radiological Physics

    1. Front Matter
      Pages 27-27
    2. Mitio Inokuti
      Pages 29-50
    3. R. H. Ritchie, R. N. Hamm, J. E. Turner, H. A. Wright, W. E. Bolch
      Pages 99-135
    4. Robert Katz, Matesh N. Varma
      Pages 163-180
  4. Early Chemical Events

    1. Front Matter
      Pages 181-181
    2. Loucas G. Christophorou
      Pages 183-230
    3. Aloke Chatterjee, William R. Holley
      Pages 257-285
    4. Clemens von Sonntag
      Pages 287-321
  5. Models of Radiation Effects

    1. Front Matter
      Pages 323-323
    2. L. A. Braby
      Pages 339-365
    3. Stanley B. Curtis
      Pages 367-386
    4. Suresh H. Moolgavkar
      Pages 387-399
  6. Molecular Radiation Biology

    1. Front Matter
      Pages 401-401
    2. John F. Ward
      Pages 403-421
    3. Roman Osman, Karol Miaskiewicz, Harel Weinstein
      Pages 423-452
  7. Summary

    1. Front Matter
      Pages 503-503
    2. William A. Glass, Matesh N. Varma
      Pages 505-512
  8. Back Matter
    Pages 513-517

About this book

Introduction

The fundamental understanding of the production of biological effects by ionizing radiation may well be one of the most important scientific objectives of mankind; such understanding could lead to the effective and safe utilization of the nuclear energy option. In addition, this knowledge will be of immense value in such diverse fields as radiation therapy and diagnosis and in the space program. To achieve the above stated objective, the U. S. Department of Energy (DOE) and its predecessors embarked upon a fundamental interdisciplinary research program some 35 years ago. A critical component of this program is the Radiological and Chemical Physics Program (RCPP). When the RCPP was established, there was very little basic knowledge in the fields of physics, chemistry, and biology that could be directly applied to understanding the effects of radiation on biological systems. Progress of the RCPP program in its first 15 years was documented in the proceedings of a conference held at Airlie, Virginia, in 1972. At this conference, it was clear that considerable progr:ess had been made in research on the physical and chemical processes in well-characterized systems that could be used to understand biological effects. During this period of time, most physical knowledge was obtained for the gas phase because the technology and instru­ mentation had not progressed to the point that measurements could be made in liquids more characteristic of biological materials.

Keywords

DNA biological effects biological materials high-pressure ionizing microscopy molecular biology

Editors and affiliations

  • William A. Glass
    • 1
  • Matesh N. Varma
    • 2
  1. 1.Pacific Northwest LaboratoriesRichlandUSA
  2. 2.U.S. Department of EnergyGermantownUSA

Bibliographic information