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The Rhabdoviruses

  • Robert R. Wagner

Part of the The Viruses book series (VIRS)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Fred Brown
    Pages 1-8
  3. Robert R. Wagner
    Pages 9-74
  4. Ranajit Pal, Robert R. Wagner
    Pages 75-128
  5. John Rose, Manfred Schubert
    Pages 129-166
  6. Craig R. Pringle
    Pages 167-243
  7. Suzanne Urjil Emerson
    Pages 245-269
  8. Gail W. Wertz, Nancy L. Davis, John Patton
    Pages 271-296
  9. John J. Holland
    Pages 297-360
  10. William H. Wunner
    Pages 361-426
  11. A. O. Jackson, R. I. B. Francki, Douwe Zuidema
    Pages 427-508
  12. Robert E. Shope, Robert B. Tesh
    Pages 509-534
  13. Back Matter
    Pages 535-544

About this book

Introduction

The viruses of the family Rhabdoviridae have an exceedingly broad host range and are widely distributed throughout the animal and plant king­ doms. Animal rhabdoviruses infect and often cause disease in insects, fish, and mammals, including man. The prototype rhabdovirus, vesicular stomatitis virus !VSV), has been extensively studied and provides perhaps the best model system for studying negative-strand viruses. The popularity of VSV as a model system is to a considerable extent due to its relative simplicity and to its rapid growth, generally to high titer, in many cell types ranging from yeast to human. The nucleocapsids of these viruses also carry transcriptional and replicative functions that are expressed in cell-free systems. The first RNA-dependent RNA poly­ merase was described in VSV and its G protein provided an early model system for studying the synthesis, processing, and membrane insertion of mammalian glycoproteins. VSV is also highly cytopathogenic and has been studied quite extensively for its capacity to kill cells and to shut off cellular macromolecular synthesis. Even earlier, VSV was discovered to be highly susceptible to the action of interferons and has served ever since as a means for quantitating the activity of interferons. To my way of thinking, the spark that ignited the explosion of re­ search in this field was struck at the First International Colloquium on Rhabdoviruses, attended by 30 or so participants in Roscoff, France, in June 1972.

Keywords

Mammalia Pathogene RNA ecology infection protein transcription virus

Editors and affiliations

  • Robert R. Wagner
    • 1
  1. 1.Department of Microbiology and Cancer CenterUniversity of Virginia School of MedicineCharlottesvilleUSA

Bibliographic information