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The Dose—Response Relation in Pharmacology

  • Ronald J. Tallarida
  • Leonard S. Jacob

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Ronald J. Tallarida, Leonard S. Jacob
    Pages 1-17
  3. Ronald J. Tallarida, Leonard S. Jacob
    Pages 19-48
  4. Ronald J. Tallarida, Leonard S. Jacob
    Pages 49-84
  5. Ronald J. Tallarida, Leonard S. Jacob
    Pages 85-110
  6. Ronald J. Tallarida, Leonard S. Jacob
    Pages 111-136
  7. Ronald J. Tallarida, Leonard S. Jacob
    Pages 137-170
  8. Back Matter
    Pages 171-207

About this book

Introduction

This book is designed to meet the modern need for a better understanding of drug-receptor interaction as applied to the gathering and interpretation of dose-response data. It is an introduction suitable for any student who has had a first course in pharmacology. This book is an extension of the pharmacology course into one area of what is now known as molecular pharmacology. The material included is an outgrowth of courses that we have given in recent years to health-science students in several professional schools and universities. The area of drug-receptor theory, although just a part of molecular phar­ macology, is already very broad. One major line of investigation is concerned with the chemical and structural nature of specific receptors and with efforts to isolate specific receptors. Another line of investigation is concerned with the kinetic theories of drug-receptor interaction, the effort there being to provide a general theory that is applicable to wide classes of drugs. We have chosen to deal with the latter. There are several reasons for our choice of topics. First, the information is very practical; that is, it permits one to use properly and consistently terms such as "efficacy," "partial agonist," "pure antagonist," "potency," "pA2'" etc., when describing drug action. Second, many students fail to appreciate the differences in and the limitations of the various theories, beginning with the classical theory of A. J. Clark, on up to the very recent allosteric theories.

Keywords

Dosis-Wirkung-Beziehung Relation drug growth pharmacology

Authors and affiliations

  • Ronald J. Tallarida
    • 1
  • Leonard S. Jacob
    • 2
    • 3
    • 4
  1. 1.Temple University School of MedicinePhiladelphiaUSA
  2. 2.Department of AnesthesiologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  3. 3.Department of PharmacologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  4. 4.Medical College of PennsylvaniaPhiladelphiaUSA

Bibliographic information